C-erbB-2和Ki-67在子宫内膜癌组织中的表达及意义

Expression and Clinical Significance of C-erbB-2 and Ki-67 in Endometrial Carcinoma

目的研究子宫内膜癌(endometrial carcinoma,EC)组织中癌基因C-erbB-2、Ki-67的表达,探讨两者与临床病理特征之间的关系。方法用免疫组化法分别检测C-erbB-2、Ki-67在63例子宫内膜癌组织和20例子宫内膜不典型增生组中的表达。结果 C-erbB-2、Ki-67在子宫内膜癌组织中的阳性率分别为82.5%、76.2%,明显高于子宫内膜不典型增生组的20.0%、15.0%(P<0.05)。C-erbB-2、Ki-67的表达和手术病理分期、组织学分级及浸润肌层深度有关差异有统计学意义(P<0.05)。Ki-67的阳性表达与淋巴结转移有关差异有统计学意义(P<0.05),C-erbB-2的阳性表达与淋巴结转移无关差异无统计学意义(P>0.05)。结论在子宫内膜癌中C-erbB-2、Ki-67过度表达,与子宫内膜癌的侵袭性有关,可作为临床医师评估子宫内膜癌预后的重要指标。

Objective To investigate the expression of C-erbB-2 and Ki-67 in endometrial carcinoma and discuss the relationship of C-erbB-2 and Ki-67 with the clinicopathological features of endometrial carcinoma.Methods To detect the expressions of CerbB-2 and Ki-67 in 63 cases of endometrial carcinoma and 20 cases of endometrial atypical hyperaplasia tissue by immunohistochemistry.Results The positive expression rates of C-erbB-2 and Ki-67 in endometrial carcinoma tissue were 82.5%,76.2%which were significantly higher than that in endometrial atypical hyperaplasia tissue 20.0%,15.0%（P0,05）.The expression of CerbB-2 and Ki-67 were related with pathological staging,histological grade and myometrial invasion depth（P〈0.05）.The positive expression of Ki-67 was related with lymph nodemetastasis（P〈0.05）,while the positive expression of C-erbB-2 was irrelevant（P〈0.05）.Conclusion The over expression of C-erbB-2 and Ki-67 are associated with the tumor invasion,and may be an important prognostic factor of endometrial carcinoma.