抑郁症患者神经心理学测验和事件相关电位N400研究

Effect of Neuropsychological Tests and Event-related Potentials N400 for Patients with Depression

目的分析神经心理学测试及事件相关电位N400对抑郁症患者治疗的临床价值。方法随机选取该院于2013年4月—2014年4月收治的30例抑郁症患者相关资料进行分析,将其设置为实验组,选择同期入院的30例非抑郁症患者作为对照组,患者入院后均进行神经心理学测试,采用MEB-9140K诱发电位仪检测事件相关电位B400,比较两组相关指标。结果实验组发病后抑郁评分为(33.87±5.62)分、焦虑评分为(42.87±6.45)分,低于对照组(P<0.05);实验组发病1 d平均波幅为(4.5±1.4)V、发病15 d平均波幅为(6.1±1.2)V、发病30 d平均波幅为(7.4±0.9)V,显著低于对照组(P<0.05)。结论抑郁症患者心理波动性比较大,且其事件相关电位N400的潜伏期在治疗前和治疗过程中有所延长,N400的平均波幅在病床不同时期有所下降。

Objective To investigate the clinical significance of neuropsychological tests and N400 event-related potentials in the treatment of patients with depression.Methods 30 patients with depression and 30 patients without depression admitted to our hospital from 2013 April to 2014 April during the same period were selected as the experimental group and control group respectively.All the 60 patients received neuropsychological tests and event-related potentials N400 detection by MEB-9140 K after admission.Relevant indicators were compared.Results The experimental group after the onset of depression score was（33.87±5.62）,anxiety score was（42.87±6.45） points lower than the control group（P〈0.05）;the experimental group,the average amplitude of the onset of one day（4.5±1.4） V,the average amplitude of the onset of 15 days（6.1±1.2） V,the average amplitude of the onset of 30days（7.4±0.9） V,significantly lower than the control group（P〈0.05）.Conclusion Volatility of patients with mental depression volatility is relatively large,and the event-related potential N400 latency period has been extended in the course of pre-treatment and treatment,the average amplitude of N400 decline in bed at different times.