瑞舒伐他汀与阿托伐他汀治疗冠心病及对血管内皮功能的影响

Clinical Efficacy of Rosuvastatin and Atorvastatin in Treatment of Coronary Heart Disease and Their Influence on Vascular Endothelial Function

目的研究瑞舒伐他汀及阿托伐他汀治疗冠心病的临床疗效及对血管内皮功能的影响。方法将该院于2011年8月—2014年7月收治的92例冠心病患者抽签随机分为观察组与对照组,观察组给予瑞舒伐他汀治疗,对照组阿托伐他汀治疗,比较两组患者治疗前后血脂水平变化及血清NO、hs-CRP、FMD水平。结果治疗后观察组TC、TG、LDL-C分别为(3.76±0.31)、(1.55±0.29)、(2.12±0.22)mmol/L与对照组(5.03±0.46)、(1.93±0.34)、(2.86±0.25)mmol/L比较显著较低(P<0.05),观察组HDL-C为(1.56±0.30)mmol/L显著高于对照组(1.42±0.22)mmol/L,对比差异有统计学意义(P<0.05);治疗后观察组NO为(105.25±9.34)μbmol/L与对照组(93.13±8.44)μbmol/L比较显著较高,Hs-CRP(2.16±0.66)mg/L与对照组(3.85±0.60)mg/L比较显著较低(P<0.05),FMD比较差异无统计学意义(P>0.05)。结论瑞舒伐他汀与阿托伐他汀均为治疗冠心病的有效方式,均可降低血脂水平,缓解炎症反应,提高血管内皮功能,而瑞舒伐他汀效果优于阿托伐他汀,可作为优选方案在临床应用。

Objective To study the clinical efficacy of rosuvastatin and atorvastatin in treatment of coronary heart disease and thier effects on vascular endothelial function.Methods 92 cases of coronary heart disease patients from 2011 August to 2014 July were randomly divided into observation group and control group,the observation group was received rosuvastatin treatment,control group was received atorvastatin treatment.Comparison on the changes in blood lipid levels and serum NO,hs-CRP,FMD level of two groups before and after treatment was done.Results After treatment,TC,TG,LDL-C of the observation group,（3.76±0.31）mmol/L,（1.55±0.29） mmol/L,（2.12±0.22） mmol/L were significantly lower than those of the control group（5.03±0.46） mmol/L,（1.93±0.34） mmol/L,（2.86±0.25） mmol/L（P〈0.05）;HDL-C of the observation group,（1.56＋0.30） mmol/L,was significandy higher than that of the control group,（1.42±0.22） mmol/L,the differences were significant（P〈0.05）;The NO in observation group after treatment（105.25±9.34） bmol/L was significantly higher than that of the control group（93.13±8.44） bmol/L;Hs-CRP（2.16±0.66）mg/L in observation group was significantly lower than that in the control group（3.85±0.60） mg/L（P〈0.05）,difference of FMD had no statistical significance（P〈0.05）.Conclusion Rosuvastatin and atorvastatin are effective ways to treat coronary heart disease,both of which can lower the level of blood lipid,alleviate the inflammatory reaction and improve vascular endothelial function.Compared with atorvastatin,the effect of rosuvastatin is better,so it can be used as the preferred scheme in clinical application.