阿立哌唑对抗精神病药物所致的老年精神分裂症患者高催乳素血症的影响分析

Effect of Aripiprazole on Hyperprolactinemia in Patients with Senile Schizophrenia Induced by Antipsychotic Drugs

目的探讨阿立哌唑对抗精神病药物所致的老年精神分裂症患者高催乳素血症的影响。方法根据治疗方法对该院于2012年5月—2014年10月收治的患者进行分组,两组患者均继续沿用原有抗精神病药物,在此基础上给予观察组患者阿立哌唑。分别测定两组治疗前、治疗4、8周末血清催乳素水平,同时采用精神病评定量表(BPRS)对精神病症状进行评定,比较两组药物不良反应。结果观察组患者治疗4周、8周末血清催乳素水平显著降低,与对照组比较,差异有统计学意义(P<0.05);两组治疗前后BPRS评分差异无统计学意义(P>0.05);两组患者药物不良反应发生率差异无统计学意义(P>0.05)。结论阿立哌唑能够有效降低抗精神病药物所致的老年精神分裂症患者高催乳素血症状,且未出现严重药物不良反应,具有有效性和安全性,可作为治疗用药。

Objective To investigate the effect of aripiprazole on hyperprolactinemia in patients with senile schizophrenia induced by antipsychotic drugs.Methods The patients from 2012 May to 2014 October in our hospital were divided according to the methods of treatment.All the patients continued to use original antipsychotic drugs,based on which patients in the observation group were given aripiprazole.Serum prolactin level before the operation,four weeks after operation,8 weeks after operation of the two groups was detected respectively;and psychiatric symptoms were assessed by Brief Psychiatric Rating Scale（BPRS）,and adverse drug reaction of the two groups was compared.Results In the observation group,serum prolactin level after 4 weeks treatment and that after 8 weeks treatment both decreased significantly,and compared with those of the control group,there were significant differences（P〈0.05）;BPRS score of the two groups before and after treatment showed no obvious difference,P〉0.05;No obvious significant difference was found in the rate of adverse drug reactions of the two groups,P〉0.05.Conclusion Without serious adverse drug reactions,and with efficacy and safety,aripiprazole can effectively improve hyperprolactinemia in patients with senile schizophrenia induced by antipsychotic drugs,so it can be used as drug treatment.