盐酸多奈哌齐对老年痴呆患者的临床治疗价值分析

Analysis of Clinical Value of Donepezil Hydrochloride for Treatment of Senile Dementia

目的探讨老年痴呆患者采取盐酸多奈哌齐治疗的临床价值。方法随机将50例老年痴呆患者均分为2组,各25例,对照组采取吡拉西坦治疗,研究组采取盐酸多奈哌齐治疗。观察记录两组临床效果,以及治疗前后简易智能精神状态检查量表(MMSE)评分与日常生活活动能力量表(ADL)评分,并对比分析。结果研究组总有效率92%,对照组总有效率72%,研究组临床总有效率明显高于对照组(P<0.05);两组治疗后MMSE与ADL评分均有改善,但研究组改善更显著(P<0.05)。结论老年痴呆患者采取盐酸多奈哌齐治疗可取得良好的效果,能明显改善患者的精神状态,提高生活活动能力,值得借鉴。

Objective To investigate the clinical value of donepezil hydrochloride in the treatment of patients with senile dementia Methods 50 patients with senile dementia were divided into two groups,with 25 patients in the control group taking piracetam treatment and the other 25 patients in the study group taking donepezil hydrochloride treatment.Clinical effects,as well as Minimental State Examination（MMSE） score before and after treatment and Activities of Daily Living Scale（ADL） score,of the two groups were observed,recorded and compared.Results Of the study group,clinical total effective rate was significantly higher（P〈0.05）;after treatment,of both of the two groups,MMSE and ADL scores were improved,but the research group improved more significantly（P〈0.05）.Conclusion For patients with senile dementia,donepezil hydrochloride treatment can achieve good results and significantly improve the patient＇s mental state,improve living activity.Therefore it is well worthy reference.