2011-2014年百色市手足口病病原学监测结果分析

Results of Pathogenic Surveillance of Hand-foot-mouth disease in Baise During 2011-2014

目的探讨百色市2011—2014年手足口病病原学特征以及流行病学特征,为临床手足口病防治提供依据。方法对该中心2011年12月—2014年12月百色市1843例手足口病病原学监测标本、重症病例和聚集性免疫患者相关资料进行综合性回顾性分析,采用Realtime RT-PCR法对患者标本进行肠道病毒通用型、肠道病毒71型(EV71)以及柯萨奇病毒A组16型(Cox A16)的特异性核酸进行检查,分析其监测结果。结果2011年阳性检出率为89.0%;2012年阳性检出率为95.7%,实验室诊断出127例;2013年阳性诊断率为95.7%,实验室诊断出699例;2014年阳性检出率为91.3%,实验室诊断出538例。结论2011—2012年百色市手足病病原体更多以EV71为主,2013—2014年以其他肠道病毒为手足口病主要病原体,EV71仍是手足口重症以及患者死亡流行趋势。

Objective To explore the characteristics of disease etiology and epidemiological characteristics of HFMD in Baise City during 2011-2014 and provide the basis for its clinical prevention and treatment. Methods The data of 1843 HFMD pathogen monitoring samples, severe cases and aggregation immune patients were comprehensively and retrospectively analyzed. The specific nucleic acid of enterovirus universal, enterovirus 71 （EV71） and Coxsackie virus group A type 16 （Cox A16） form the specimens were inspected by Realtime RT-PCR and the test results were analyzed. Results The positive rates in 2011, 2012, 2013, 2014 were 89.0%; 95.7%, 95.7% and 91.3% respectively, and there were 127 patients, 699 patients, 538 patients diagnosed in 2012, 2013, 2014 respectively. Conclusion During 2011-2012, EV71 was the main pathogens of HFMD in Baise, and during 2013-2014 other enteroviruses instead. But EV71 is still the pathogens that can cause severe HFMD and the death of patients.