多发性硬化应用β干扰素鞘内注射治疗的效果分析

Effect of Intrathecal Injections of β-interferon in Treatment of Multiple Sclerosis

目的探讨β干扰素(IFN-β)经鞘内注射治疗多发性硬化(MS)的疗效。方法整群选取2013年1月—2014年6月该院收治的76例MS患者随机分为观察组与对照组,各38例。对照组予以常规治疗,观察组在对照组的基础上加用IFN-β鞘内注射,比较两组的疗效。结果观察组的治疗总有效率为92.11%,显著高于对照组的81.58%(P<0.05);两组治疗后ADL均显著提高,且观察组显著高于对照组(P<0.05);治疗后两组NDS均显著降低,且观察组显著低于对照组(P<0.05);两组的不良反应率对比差异无统计学意义(P>0.05)。结论IFN-β经鞘内注射辅助治疗MS能够改善患者的生活质量及神经功能障碍,提高临床疗效,不良反应少,值得推广应用。

Objective To investigate the effect of intrathecal injections of β-interferon in the treatment of multiple sclerosis. Meth-ods 76 patients with MS admitted to our hospital between June 2013 and June 2014 were randomly divided into two groups, each of 38 cases. Patients in the control group received conventional treatment based on which those in the observation group were treated with IFN-β intrathecal injection. Efficacy of the two groups were compared. Results The total effective rate of observation group 92.11%, was significantly higher than that of the control group 81.58%（P〈0.05）;ADL of both of the two groups after treat-ment were significantly improved, and the observation group was significantly higher than the control group （ P 〈0.05）;After treat-ment, NDS of the two groups were significantly reduced, and the observation group was significantly lower than the control group （P〈0.05）;adverse reaction rates between the two groups had no significant difference （P〉0.05）. Conclusion Assistant treatment of intrathecal injections ofβ-interferon in the treatment of multiple sclerosis can improve the quality of life and neurological dysfunc-tion and clinical efficacy. With less adverse reactions, it should be widely applied.