老年痴呆患者采用依达拉奉辅助治疗的临床效果研究

Clinical Effect of Edaravone Adjuvant Treatment for Senile Dementia

目的探讨依达拉奉辅助治疗老年痴呆的临床疗效。方法整群选取2013年1月—2014年10月该院收治的64例老年痴呆患者随机分为观察组与对照组,各32例。对照组予以常规治疗,观察组在对照组的基础上加用依达拉奉治疗,比较两组的疗效。结果观察组治疗总有效率为90.6%,显著高于对照组的78.1%(P<0.05);治疗后两组的MMSE、HDS及ADL评分均较治疗前显著改善,且观察组改善幅度更为显著(P<0.05)。结论依达拉奉辅助治疗老年痴呆有利于改善患者的智力状态及生活能力,提高临床疗效,值得推广应用。

Objective To investigate the clinical efficacy of edaravone adjuvant treatment for senile dementia. Methods 64 cases of Alzheimer＇s patients were randomly divided into observation group and control group, 32 cases in each. Patients in the control group received conventional treatment based on which those in the observation group were given edaravone treatment, and efficacy was compared between the two groups. Results The total effective rate of the observation group ,90.6%, was significantly higher than that of the control group, 78.1% （P 〈0.05）; After treatment, the MMSE, HDS and ADL scores of the two groups were significantly improved than those before treatment, and the magnitude of the improvement in the observation group was more significant （P 〈0.05）. Conclusion Edaravone adjuvant treatment for senile dementia is helpful to the improvement of patients ’ mental status and viability and clinical efficacy, so it should be widely applied.