贝那普利在2型糖尿病肾病患者中的应用及对其血清抵抗素水平的影响

Application of Benner Pury in Patients with Type 2 Diabetic Nephropathy and Its Influence on Serum Resistin Level

目的探讨贝那普利在2型糖尿病肾病患者中的应用及对其血清抵抗素水平的影响。方法将随机抽取2013年10月—2014年10月在该院内分泌科治疗的100例2型糖尿病肾病患者随机分为两组,对照组采用常规治疗的方法,观察组在此基础上给予贝那普利治疗,比较两组患者的治疗效果、血糖水平、血清抵抗素水平、肾功能。结果观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);观察组空腹血糖、餐后2h血糖、糖化血红蛋白明显较对照组改善,差异有统计学意义(P<0.05);观察组治疗后血清抵抗素水平明显低于对照组,差异有统计学意义(P<0.05);观察组BUN、Cr、24hUA明显较对照组改善,差异有统计学意义(P<0.05)。结论贝那普利在2型糖尿病肾病患者的治疗中效果显著,可降低血清抵抗素水平,改善病情进程。

Objective To study application of benner pury in patients with type 2 diabetic nephropathy and its influence on serum resistin level. Methods 100 patients with type 2 diabetic nephropathy treated in the Department of Endocrinology in our hospital between October 2013 and October 2014 were randomly divided into two groups： patients in the control group were given conven-tional treatment based on which those in the observation group were given benner pury. The curative effect, blood glucose, serum resistin levels and renal function of the two groups were compared. Results The treatment efficient of the observation group was obviously higher than that of the control group, and the difference was statistically significant （P〈0.05）;In the observation group, compared with those in the control group, fasting blood glucose, 2h postprandial blood glucose and glycosylated hemoglobin were improved obviously, and the differences were statistically significant （P〈0.05）;Of the observation group, serum resistin level after treatment was significantly lower than that of the control group, and the difference was statistically significant （P〈0.05）;Of the ob-servation group, BUN, Cr, 24 hUA were improved obviously than those of the control group, and the differences were statistically significant （P〈0.05）. Conclusion The effect of benner pury in the treatment of patients with type 2 diabetic nephropathy is signif-icant, and it can decrease the serum resistin levels and improve disease process.