莫西沙星和左氧氟沙星在耐多药肺结核病治疗方案中的效果比较

Comparison of Clinical Effect of Moxifloxacin and Levofloxacin in treatment of Multi-Drug Resistant Pulmonary Tuberculosis

目的临床使用莫西沙星及左氧氟沙星治疗耐多药肺结核病,比较其临床作用效果。方法选取60例2012年9月—2014年10月该所经确诊为耐多药肺结核病患者临床资料进行回顾性分析,根据用药原则不同分成左氧氟沙星组与莫西沙星组,每组各为30例。两组均进行统一基础抗结核方案治疗,并各自加用所选择药物。分别对两组临床治疗效果进行观察并作比较。结果莫西沙星组整体治疗有效率为93.33%,左氧氟沙星组整体治疗有效率为80.00%,比较结果显示莫西沙星组治疗效果更为显著,P<0.01;统计两组不良反应发生率,莫西沙星组为26.67%,左氧氟沙星组为23.33%,比较基本无差异,P>0.05。结论莫西沙星治疗耐多药肺结核效果显著,引起的不良反应较少,临床可推广应用。

Objective To compare the clinical effects of moxifloxacin and levofloxacin in the treatment of multi-drug resistant pul-monary tuberculosis. Methods The clinical data of 60 patients with multi-drug resistant pulmonary tuberculosis confirmed in our hospital from September 2012 to October 2014 was retrospectively reviewed. The patients were divided into levofloxacin group and moxifloxacin group according to different medication principles, 30 cases in each group. Two groups adopted the unified basic treatment and separately chose the different drugs. The clinical treatment effect of two groups was observed and compared. Results The total effective rate of the moxifloxacin group （93.33%） was significantly higher than that of levofloxacin group （80.00%） （ P〈0.01）;the adverse event rate of the moxifloxacin group and the levofloxacin group was 26.67%and 23.33% （P〉0.05）. Conclusion Moxifloxacin has an obvious treatment effect in multi-drug resistant pulmonary tuberculosis and fewer adverse reactions. It is wor-thy of clinical promotion and application.