云南省乳腺癌患者临床流行病学特征分析

The Epidemiological Characteristics of Breast Cancer Patients in Yunnan Province

目的初步了解云南省乳腺癌患者的临床流行病学特征,为乳腺癌的防治提供依据和建议。方法回顾性分析1094例西部肿瘤系统中2004年1月—2013年12月在云南省肿瘤医院乳腺科确诊并治疗的全部乳腺癌患者临床流行病学特征。结果患者发病年龄为21-82岁,平均年龄（48.52±9.90）岁,中位年龄48岁,发病高峰在41-50岁。肿块位置以外上象限为主,病理类型以浸润性导管癌为主,临床分期以II期为主,占66.0%。手术方式以改良根治术为主,ER阳性率64.9%,PR阳性率62.9%,HER-2阳性率为10.7%。按≤50岁和〉50岁分成两个组,分析不同年龄组之间各因素的情况,结果显示不同年龄组之间怀孕生产史（P=0.001）、哺育史（P=0.001）、ER（P=0.001）、PR（P=0.007）、Ki-67（P=0.0042）差异有统计学意义,其余差异均无统计学意义（P〉0.05）。按汉族和少数民族分成两个组,分析不同民族之间各因素的情况,结果显示不同民族之间除ER（P=0.024）差异有统计学意义,其余差异均无统计学意义（P〉0.05）。分析不同文化程度之间各因素的情况,结果显示不同文化程度之间除生产次数（P=0.018）差异有统计学意义,其余差异均无统计学意义（P〉0.05）。结论云南省乳腺癌患者发病年龄趋于年轻化,其发病高峰、肿块位置、病理类型与其他相关研究结果相符。未发现不同民族、不同文化程度会影响乳腺癌的发生发展。早期乳腺癌诊断比率低,手术方式以改良根治术为主,需加大偏远山区普查力度,加强＂自查＂宣教,做到早发现、早诊断、早治疗。

Objective To preliminary investigate the epidemiological characteristics of breast cancer patients in yunnan Province,providing evidence and recommendations for the prevention and treatment of breast cancer. Methods A retrospective analysis of clinical epidemiological characteristics on 1094 cases of all diagnosed breast cancer patients from January 2004 to December 2013 in Breast Department of Yunnan Tumor Hospital in Western Tumor System was done. Results The onset age was 21 -82, with mean age（48.52±9.90）, and a median age of 48, the peak incidence was at 41-50. Ceiling outside was the main tumor position,invasive ductal carcinoma was the main histological type, and with clinical stage II, which accounting for 66.0%. modified radical mastectomy was dominated surgical approach, ER-positive rate was 64.9%, PR positive rate was 62.9%, HER-2-positive rate was10.7%, two groups were formed according to less than or equal to 50 and 〉50, there was significant difference in pregnant production history（P=0.001）, feeding history（P=0.001）, ER（P=0.001）, PR（P=0.007）, and Ki-67（P=0.0042） between different age groups, while other factors had no significant difference（P〉0.05）. Two groups were divided by Han and minority, factor analysis between the different ethnic groups were made, which showed that there was no significant difference（P〉0.05）, in addition to ER（P=0.024）. The analysis of factor among different cultural levels, showed that there was no significant difference（P〉0.05）, in addition to production times（P=0.018）. Conclusion The breast cancer patients of yunnan province tend to younger, and the incidence peak, mass position and histological type were consistent with other findings. Different nationalities and education level would not be able to affect the development of breast cancer. Early diagnosis of breast cancer had low rate, modified radical mastectomy was dominated surgical approach, the remote mountainous census need to be improved, and ＂self-examination＂ missionary should be strengthened, so that early detection, early diagnosis and early treatment could be achieved.