氨磺必利与舒必利治疗成年女性精神分裂症临床对比探讨

Clinical Contrast Observation of Amisulpride and Sulpiride in Treating Adult Female Schizophrenia

目的探讨成年女性精神分裂症应用氨磺必利与舒必利的效果,以丰富临床治疗经验。方法随机选择该院2013年6月—2014年6月接收并确诊的精神分裂症的成年女性患者100例,根据入院治疗顺序随机分成对照组与观察组各50例,对照组通过舒必利治疗,观察组则通过氨磺必利予以治疗,经8周治疗后,统计两组患者的治疗总有效率及不良反应发生率,并将结果进行对比。结果经治疗后,患者的临床症状均有明显的改善与缓解,观察组治疗的总有效率为86.00%,对照组的为84.00%,比较差异无统计学意义(P>0.05);另外,经治疗后,两组的PANSS评分都显著低于治疗前的评分(P<0.05),但两组治疗后的PNASS评分比较差异无统计学意义(P>0.05)。观察组中5例治疗期间出现不良反应,不良反应率10.00%,对照组中13例不良反应,不良反应率26.00%,两组对比差异具有统计学意义(P<0.05)。结论成年女性精神分裂症应用氨磺必利与舒必利治疗效果相当,但是舒必利的不良反应率偏高,在临床治疗中应谨慎用药。

Objective To investigate the effect of amisulpride and sulpiride in treating adult female schizophrenia to rich clinical treatment experience. Methods 100 adult female with schizophrenia in our hospital were selected. They were divided into control group and observation group, 50 cases in each group. The control group was given sulpiride and the observation group was given amisulpride. Compared the total efficiency and adverse reaction rate of the two groups. Results After treatment, clinical symptoms of the two groups had obvious improvement and relief. Total efficiency of observation group was 86.00%, control group was84.00%, the difference was not statistically significant（P〈0.05）. Otherwise, PANSS score of the two groups were obviously lower than before treatment（P〈0.05）. But after treatment, the difference of PANSS score of the two groups was not statistically significant（P〉0.05）. 5 cases in observation group had adverse reactions, the adverse reaction rate was 10.00%. 13 cases in control group had adverse reactions, the adverse reaction rate was 26.00%, the difference of the two groups was statistically significant（P〈0.05）.Conclusion Amisulpride and sulpiride in treating adult female schizophrenia have same effect, but adverse reaction rate of sulpiride is higher and should be used carefully in clinical treatment.