神经节苷脂钠联合高压氧治疗对新生儿缺氧缺血性脑病的临床效果探究

Clinical Observation of Gangliosides and Hyperbaric Oxygen Therapy in Neonates with Hypoxic Ischemic Encephalopathy

目的对神经节苷脂钠联合高压氧治疗对新生儿缺氧缺血性脑病的临床效果进行探讨。方法整群选取2012年6月—2013年6月于该院进行治疗的104例新生儿缺氧缺血性脑病患者,将其随机分为对照组51例与观察组53例。对照组使用常规治疗方法,观察组给予神经节苷脂钠联合高压氧治疗。观察并评价治疗效果及NABA评分比较,疗程为30 d。结果观察组总有效率高达96.2%,显著优于对照组的85.3%,差异有统计学意义(P<0.05);治疗后,NBNA评分观察组(38.8±3.6),显著高于对照组(34.2±3.4),表明观察组改善程度更为显著,差异具有统计学意义(P<0.05)。结论联合运用神经节苷脂钠和高压氧对新生儿缺氧缺血性脑病的治疗效果显著好于用常规治疗方法,临床医生治疗新生儿缺氧缺血性脑病可以优先考虑该方法。

Objective To observe the efficacy of the gangliosides and hyperbaric oxygen therapy in the treatment of neonates with hypoxic ischemic encephalopathy.Methods From June 2012 to June 2013, 104 cases with Hypoxic-ischemic encephalopathy were selected and randomly divided into observation group with 53 cases and control group with 51 cases. The control group was treated with conventional treatment; the observation group was treated with gangliosides and hyperbaric oxygen therapy. Then compare the clinical efficacy and NABA scores after treatment between the two groups. Results After treatment, the total effective rate of observation group was 96.2%, the total effective rate of the control group was 85.3%, and the difference was statistically significant（P〈0.05）. NABA score of observation group was38.8 ±3.6, NABA score of observation group was 34.2 ±3.4, observation group increased more significantly than the control group（P〈0.05）. Conclusion Gangliosides and hyperbaric oxygen therapy in the treatment of neonates with hypoxic ischemic encephalopathy have significant effect, can shorten the course of treatment, it is worthy of promotion.