同型半胱氨酸联合脑钠肽检测在维持性血液透析患者中的应用

The Application with Homocysteine and Brain Natriuretic Peptide in Maintenance Hemodialysis Patients

目的探讨同型半胱氨酸(Hcy)联合脑钠肽(BNP)检测在维持性血液透析(MHD)中的应用价值。方法随机选取2010年1月—2015年1月与该院进行维持性血液透析治疗的尿毒症患者116例作为研究对象,选择50例健康体检患者为对照组。所有患者均行维持性血液透析1年以上,已排除失访病例。采集所有患者血液透析前后外周静脉血进行检查,应用放射免疫法检测透析前后BNP、Hcy指标,并根据患者透析后心血管风险事件发生率分析Hcy联合BNP在MHD中检测意义。结果血透组患者透析前Hcy、BNP指标均高于透析后(P<0.05),并且透析前后Hcy、BNP指标均明显高于对照组(P<0.05);随访复查中发生心血管疾病63例,其透析前后BNP及Hcy指标明显高于无并发心血管疾病患者,差异有统计学意义(P<0.05)。结论BNP联合Hcy检测可作为维持性血液透析患者心血管风险事件发生的高危预警因素,具有临床应用及推广价值。

Objective To discuss the Application with Homocysteine and brain natriuretic peptide in maintenance hemodialysis patients. Methods Selected 116 hemodialysis in uremic as study from January 2010 to January 2015 in our hospital, and selected50 healthy people as a control group. All patients were performed maintenance hemodialysis more than 1 year, excepted those lost to follow-up. Collected all patients＇ peripheral venous blood before and after hemodialysis and used ria method to detect the BNP and Hcy. The incidence of cardiovascular events risk analysis Hcy joint significance of BNP testing in accordance with MHD patients after dialysis. Results Hemodialysis patients before dialysis Hcy, BNP indicators were higher than after dialysis（P〉0.05）,and before and after dialysis Hcy, BNP indicators were significantly higher（P0.05）; 63 patients with cardiovascular disease in the follow-up review, BNP and its front and rear dialysis Hcy index than those without concurrent cardiovascular disease, P0.05, statistically significant. Conclusion BNP and Hcy detect high-risk warning as cardiovascular risk factors in maintaining blood incident dialysis patients, with clinical applications and promotional value.