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腺病毒组织特异性启动子在泌尿系肿瘤的研究进展

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摘要 近几年来,肿瘤标记物的研究越来越热门,越来越多的肿瘤标志物已经在临床上使用.通过把这些特异性的标志物,作为腺病毒的启动子,靶向进入肿瘤细胞发挥作用.其特异性的启动子主要的作用是特异性的调控腺病毒E1A基因的表达,使病毒DNA更容易在细胞中复制,从而溶解肿瘤细胞,并向周围扩散,发挥级联效应.本文将通过近些年对组织特异性启动子腺病毒在前列腺癌、膀胱癌、肾癌中的研究进行阐述。
出处 《国际泌尿系统杂志》 2015年第6期926-929,共4页 International Journal of Urology and Nephrology
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