米非司酮配伍依沙吖啶在中期妊娠引产中的临床效果观察

Effect observation of mifepristone combined with ethacridine in midtrimester pregnancy abortion

目的观察米非司酮配伍依沙吖啶羊膜腔内注射用于中期妊娠引产的临床效果。方法将200例中期妊娠要求引产孕妇随机分为观察组及对照组各100例,观察组给予米非司酮配伍依沙吖啶羊膜腔内注射引产,对照组行依沙吖啶羊膜腔内注射引产。观察2组依沙吖啶羊膜腔注射至宫缩发动时间,宫缩发动时至胎儿排出时间,引产成功例数,产后2h出血量,胎盘、胎膜残留情况,宫颈裂伤例数,难忍性疼痛例数情况。结果观察组依沙吖啶羊膜腔注射至宫缩发动时间、宫缩发动时至胎儿排出时间及总产程均短于对照组,差异均有统计学意义(P<0.05)。2组引产成功率比较差异无统计学意义(P>0.05)。观察组宫缩时宫颈Bishop评分高于对照组,产后2h出血量少于对照组,胎盘、胎膜残留、宫颈裂伤、宫缩引起难忍性疼痛的发生率均低于对照组,差异均有统计学意义(P<0.05)。结论米非司酮联合依沙吖啶引产可有效地软化宫颈,避免宫颈裂伤,加快胎儿胎盘排除时间,减少产后出血量,减轻患者因引产带来的难忍性疼痛,有助于产后恢复。

Objective To observe the effect of mifepristone combined with ethacridine in midtrimester pregnancy abortion. Methods 200 pregnant women of midtrimester pregnancy requires abortion were randomly divided into observation group and control group,each of 100 cases. Observation group used mifepristone combined with ethacridine amniotic injection induction,control group used ethacridine amniotic injection induction. Observed the ethacridine amniotic injection to contractions launch time,uterine launch to fetus ejection time,successful induction situation,postpartum 2h bleeding volume,placenta,fetal membranes residue situation,the number of cases of cervical lacerationcases and the number of cases of unbearable pain.Results The ethacridine amniotic injection to contractions launch time,uterine launch to the fetus ejection time and the total production process of observation group were shorter than those of control group,the differences were statistically significant（ P〈0. 05）. The induction success rate of two groups was no significant difference（ P〉0. 05）. The uterine cervix Bishop score of observation group was lower than control group,the postpartum hemorrhage 2h was less than control group,the incidence of placenta,fetal membranes residues,cervical laceration,unbearable pain were lower than control group,the differences were statistically significant（ P〈0. 05）. Conclusion Mifepristone combined with ethacridine induction can effectively soften the cervix,avoid cervical laceration,accelerate fetal placenta time,reduce postpartum bleeding volume,reducing patient unbearable pain due to induced labor,help to postpartum recovery.