肥胖2型糖尿病患者合并高尿酸血症的相关因素分析及疾病认知情况调查

Analysis of Relevant Factors and Investigation on Recognition of Hyperuricemia in Obese Type 2 Diabetes

目的探讨肥胖2型糖尿病患者中无症状高尿酸血症(HUA)的发生率、HUA的相关影响因素,以及HUA患者的疾病认知情况。方法测定142例肥胖2型糖尿病患者、46例非肥胖尿酸正常的2型糖尿病患者和63例健康体检人群的BMI、尿酸、血糖、糖化血红蛋白、血脂谱等指标,根据尿酸水平将肥胖组分为HUA组和尿酸正常组,比较各组的指标差异情况,分析尿酸与其他指标的相关性。对HUA患者发放调查问卷,了解其对HUA的认知情况。结果 HUA组BMI、甘油三酯水平更高(P<0.05)。BMI、甘油三酯与血尿酸水平呈正相关(r分别为0.306、0.259),男性、BMI、甘油三酯对血尿酸有影响。HUA患者对疾病认知不足,了解不深。结论 HUA与性别、肥胖及2型糖尿病等因素有关,其原因是多方面的,有些具体机制尚不明确。医务工作者应加强对HUA的宣教。

Objective To study the morbidity rate of hyperuricemia（HUA） in obese type 2 diabetes,the effect factors of HUA,and the patients＇recognition. Methods Blood samples were collected from 142 obese type 2 diabetes patients and 46 non - obese normal uric acid type 2 diabetes and 63 healthy persons. BMI, uric acid, fasting plasma glucose, HbAlc and cholesterol, triglycerides, HDL - cho- lesterol and LDL - cholesterol were measured. Obese diabetes patients were divided into HUA group and normal uric acid group according to the level of plasma uric acid. The differences of assay indexes among different groups were compared. The correlations between uric acid and other clinical parameters were analysized. Furthermore, the questionnaires from HUA patients were collected to know their HUA rec- ognition. Results The levels of BMI and triglycerides increased significantly in HUA group （ P 〈 0.05 ）. The unic acid level was positively related with BMI and triglycerides levels. （r = 0. 306,0. 259 ）. HUA was effected by male, BMI and triglycerides, respectively. Most HUA patients had less knowledge about the illness. Conclusion HUA was related with sexuality,obesity and type 2 diabetes. The reasons are muhifactorial, some pathogenesis have not been fully explained. It is important for doctors to pay more attention to propaganda and educa- tion on HUA.