摘要
目的 研究非糖尿病患者中,胰岛素抵抗是否和冠状动脉粥样硬化形成具有独立的相关性。方法 该试验入选2008年~2014年通过冠状动脉造影明确诊断为急性心肌梗死非糖尿病患者,测定胰岛素抵抗,根据稳态模型评估胰岛素抵抗指数将研究对象四分位法分为1、2、3和4组,分析患者人口统计学、临床特征和低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、甘油三酯(TG)、糖化血红蛋白和超敏C反应蛋白(hs-CRP)等新陈代谢因子,基于Poisson回归模型,判断评估非糖尿病患者胰岛素抵抗与冠状动脉粥样硬化的相关性。结果 入院研究对象共1 073例,平均年龄为56岁,女性占28.9%,4组患者多支血管病变发生率分别为37.8%、42.3%、47.2%和48.0%(P=0.009)。多变量分析中,同四分位1组相比,四分位3组[RR(95%CI)=1.31(1.07~1.60)]和4组[RR(95%CI)=1.29(1.03~1.60)]与多支血管病变具有独立的相关性。结论 该研究表明急性心肌梗死非糖尿病患者中,胰岛素抵抗与多支血管病变具有独立的相关性。
[Objective] To assess the association between insulin resistance and clinically significant an- giographic atherosclerosis in non-diabetic patients. [Methods] The association between insulin resistance and the extent of coronary atherosclerosis determined by angiography was examined in non-diabetic patients sur- viving acute myocardial infarction (AMI) between 2008 to 2014. The patients were divided into 4 groups based on the homeostasis model assessment grading of insulin resistance (HOMA-IR). We assessed whether insulin resistance was independently associated with clinically significant angiographic atherosclerosis in non- diabetic patients. [Results] Overall, the cohort had 1,073 people with a median age of 56 years and women accounting for 28.9%. The crude prevalence of MVD was 37.8%, 42.3%, 47.2% and 48.0% for the HOMA- IR groups 1, 2, 3 and 4 respectively (P= 0.009). In multivariable modeling, compared with the group 1, both the groups 3 [RR (95%CI) = 1.31 (1.07-1.60)] and 4 [RR (95%CI) = 1.29 (1.03-1.60)] were independently associated with MVD. Covariates in the model included patient demographic and clinical characteristics and metabolic factors (LDL-C, HDL-C, triglyeeride, HbAlc and hs-CRP). [Conclusion] There is an independent association between insulin resistance and MVD in non-diabetic post-AMI patients.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第33期44-50,共7页
China Journal of Modern Medicine
关键词
动脉粥样硬化
胰岛素抵抗
急性心肌梗死
atherosclerosis
insulin resistance
acute myocardial infarction