运动降低冠心病发病率与血浆氧化低密度脂蛋白低水平相关

Sport prevents the occurrence and development of coronary heart disease accociated with low plasma Ox-LDL level

目的探讨运动降低冠心病发病率与血浆氧化低密度脂蛋白(oxidized low density lipoprotein,OxLDL)低水平相关。方法健康体检者和急性心梗(acute myocardial infarction,AMI)患者根据有无高血脂分为常脂组和高脂组,再根据有无运动习惯进一步分为运动组和对照组,观察血脂参数总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白及Ox-LDL的水平,并分析AMI患者的血管病变程度。结果与健康体检者相比,无论是高脂还是常脂的AMI患者血浆Ox-LDL水平均明显升高。运动组的血浆Ox-LDL水平比相应对照组低,但其他血脂参数的差异不大。在AMI患者中,运动组多支冠状动脉损害较对照组轻微。结论运动抑制冠心病的发生发展与血浆Ox-LDL低水平可能相关,培养运动习惯可在一定程度上抑制冠心病的发生发展。

Objective To explore whether the occurrence of coronary heart disease prevented by sport has relationship to the low level of plasma oxidized low density lipoprotein（Ox-LDL）. Methods Healthy subjects and patients with acute myocardial infarction（AMI）were recruited in the trial and were devided into hyperlipidemia group and ortholiposis group,respectively,which were re-devided into sport group and control group.The plasma lipids parameters,such as TC,TG,HDL,LDL and Ox-LDL,were evaluated,and the vascular damage was analyzed in AMI patients. Results Plasma Ox-LDL level was significantly increased in AMI patients compared to healthy subjects.Sport greatly decreased plasma Ox-LDL level either in healthy subjects with hyperlipidemia or in AMI patients with or without hyperlipidemia,although it had little effect on other plasma lipids level.In AMI patients,multi-vessel damage in sport group was better than that in control group. Conclusions The high level of Ox-LDL may be one of critical factors for the occurrence and development of coronary heart disease.Sport could prevent the occurrence and development of coronary heart disease in subjects with or without hyperlipemia,which is associated with low Ox-LDL level in plasma.