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心肌梗死相关微RNA的研究进展

Progress of microRNAs related to myocardial infarction
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摘要 微RNA(microRNAs,miRs)是一类非编码RNA,能够调控基因组中大部分基因的表达。心肌梗死(myocardid infarction,MI)常伴随基因表达谱的改变和相关信号通路的失调。miRs在MI中扮演重要角色,其对心肌细胞的存活及缺血后血管生成有着多方面的调控作用。MI后miRs表达升高或下降可能参与心脏整体功能的调节。本文总结了MI相关miRs的最新进展,并讨论了miRs应用于MI治疗中的前景和局限性。 MicroRNAs（miRs）are noncoding RNAs that control a large fraction of the genome.Myocardial infarction（MI）is characterized by strongly altered gene expression,deregulation of underlying signaling pathways and crucial participation of several miRs.miRs plays an important role in MI,and have multiple effects on the survival of cardiomyocytes and post ischemic angiogenesis.After MI miRs induction or repression might regulate overall cardiac function.In this review,we summarize the current knowledge about several miRs after MI and discuss briefly the application and limitations of miRs in treating MI.
作者 王宁 文平
机构地区 大连医科大学附属大连市儿童医院心脏中心 第四军医大学生物医学工程系
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2015年第6期790-794,805,共6页 Fudan University Journal of Medical Sciences
基金 国家自然科学基金(81102687)~~
关键词 微RNA 心肌梗死 纤维化 血管生成 microRNA myocardial infaction fibrosis angiogenesis
分类号 R542.22 [医药卫生—心血管疾病]
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复旦学报（医学版）
2015年 第6期

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