四逆散加减治疗胃食管反流病引起的慢性咳嗽临床观察

Observation of Modified Sini San for Cough Induced by Gastroesophageal Reflux Disease

目的:观察四逆散加减治疗胃食管反流病引起的慢性咳嗽临床疗效。方法:将136例患者随机分为2组,各68例。治疗组给予加味四逆散治疗;对照组给予西医常规治疗(奥美拉唑胶囊,硫糖铝悬液,吗丁啉片)。比较2组患者治疗前后进行胃镜检查,24h食管p H值监测,食管测压[食管测压(LESP)、食管下端括约肌长度(LESL)、食管下端蠕动幅度]等。结果:2组治疗后LESP、LESL、食管体下端蠕动振幅比较,差异无统计学意义(P>0.05)。治疗后2组各项指标均有改善,与本组治疗前比较,差异有统计学意义(P<0.05);治疗后2组各项指标比较,差异有统计学意义(P<0.05)。治疗前2组胃镜分级比较,差异无统计学意义(P>0.05);治疗后治疗组与对照组比较,差异有统计学意义(P<0.05)。总有效率治疗组88.2%,对照组82.4%,2组比较,差异有统计学意义(P<0.05)。结论:四逆散加减治疗对改善胃食管反流病引起的慢性咳嗽有着积极的作用,保护了食管黏膜,促进炎症的修复,临床安全性高。

Objective： To observe the effect of modified Sini san for cough induced by Gastroesophageal Reflux Disease （GERD）. Methods：One-hundred and thirty-six patients were randomly divided into two groups, the treatment group with 68 examples were given modified Sini san, and the control group with other 68 cases were treated with conventional western medicine therapy（omeprazole capsules, sucralfate suspension, Motihium）. Gastroscopy before and after treatment, 24 h esophageal pH monitoring, and esophageal pressure of both groups were compared. Results： The difference of lower esophageal sphincter pressure（LESP）, lower esophageal sphincter length（LESL）, and lower esophagus peristalsis amplitude after treatment between the two groups were insignificant （P 〉 0.05）. The difference of 24 h esophageal pH monitoring andgastroscopy grade after treatment between the two groups were significant （P 〈0.05）. The levels of 24h esophageal pH monitoring in both groups after treatment were significantly improved （P 〈 0.05 compared with before treatment）, The tota effective rate was 88.2% in the treatment group, and was 82.4% in the control group, the difference being insignificant（P〉 0.05）. Conclusion.- Modified Sini san has positive effect on improve cough induced by GERD, and can protect esophagea mucosa, promote renovation of inflammation with high clinical safety.