绝经后女性非酒精性脂肪性肝病与骨生化指标的相关性研究

Correlation between nonalcoholic fatty liver disease and bone biochemical indicators in postmenopausal women

目的探讨绝经后女性非酒精性脂肪性肝病(NAFLD)患者血脂指标和骨生化指标的相关性。方法选择新疆医科大学第一附属医院2014年7月-2015年8月800例受试者,按照1∶1病例对照研究设计原则,病例组和对照组中维吾尔族、汉族各200例。检测所有受试者的血脂指标,包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、脂蛋白a(LP-a)及游离脂肪酸(NEFA)。骨生化指标包括血清骨特异性碱性磷酸酶(s-BAP)、骨钙素(OT)、Ⅰ型胶原氨基末端肽(s-NTX)、抗酒石酸酸性磷酸酶(Tr ACP),并进行相关性分析。结果病例组TG、TC、HDL-C、LDL-C、LP-a和NEFA指标均明显高于对照组,差异具有统计学意义(P<0.05);TG、TC、HDL-C、LDL-C、LP-a、NEFA和s-BAP与OT、s-NTX、Tr ACP均有相关性(P<0.05),其中s-BAP与LDL-C呈显著正相关(r=0.817,P=0.022),OT与NEFA呈显著负相关(r=-0.766,P=0.031),s-NTX与TC呈显著正相关(r=0.841,P=0.021),Tr ACP与TG呈显著正相关(r=0.812,P=0.025)。结论绝经后女性非酒精性脂肪性肝病患者血脂指标与骨生化指标有一定的相关性,有助于对绝经后女性非酒精性脂肪性肝病患者发生骨代谢异常的预防、诊断和治疗。

Objective To explore the correlation between nonalcoholic fatty liver disease blood lipid indicators and bone biochemical indicators in postmenopausal women. Methods During July of 2014 to August of 2015,800 cases were selected from people who were physically examined in the First Affiliated Hospital of Xinjiang Medical University as the subjects. According to the design principle of 1 ∶ 1 case control study,400 cases of patients and control group,200 cases of Uygur and Han nationality in case group and control group. The blood and bone biochemical markers were detected and the correlation analysis was carried out. Results Triglyceride（ TG）,total cholesterol（ TC）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C）,lipoprotein a（ LP-a）,non esterified fatty acid（ NEFA） in the case group were significantly higher than those in the control group and had statistical significance（ P〈0. 05）. TG,TC,HDL-C,LDL-C,LP-a,NEFA and s-BAP,OT,sNTX,Tr ACP have correlation（ P〈0. 05）. s BAP and LDL-C were significantly positively correlated（ r = 0. 817,P= 0. 022）,OT and NEFA were significantly negatively correlated（ r =- 0. 766,P = 0. 031）,s-NTX and TC were significantly positively correlated（ r = 0. 841,P = 0. 021）,Tr ACP and TG were significantly positively correlated（ r = 0. 812,P =0. 025）. Conclusion There is a certain correlation between the serum index and the bone biochemical parameters of the non-alcoholic fatty liver disease in postmenopausal women. And this study was contribute to diagnosis and treatment of abnormal bone metabolism in postmenopausal women with non-alcoholic fatty liver disease.