摘要
犬尿氨酸通路是色氨酸代谢的主要途径,与亨廷顿病、阿尔茨海默病、帕金森氏症等神经退行性疾病的发生、发展有着密切联系。本文主要综述了犬尿氨酸通路代谢产物的神经生物学活性及其与相关神经退行性疾病的关系,为研究和治疗神经退行性疾病提供新的思路和方法。
The kynurenine pathway,a major route of tryptophan metabolism,is involved in the occurrence and development of some neurodegenerative diseases,such as Huntington＇s disease,Alzhermier＇s disease and Parkinson＇s disease. This article is focused on the literature review on the neurobiological properties of kynurenine pathway metabolites and their crucial role in related neurodegenerative diseases, for providing novel therapeutic interventions to neurodegenerative diseases.
出处
《中国比较医学杂志》
CAS
北大核心
2015年第11期69-75,共7页
Chinese Journal of Comparative Medicine
基金
科技部对欧盟科技合作专项(1108)
新疆科技厅资助项目(20146021和201491174)
