437例癫痫患儿血丙戊酸浓度监测分析

Analysis of Serum Concentrations of Valproic Acid in 437 Patients with Pediatric Epilepsy

目的：分析癫痫患儿血丙戊酸（VPA）水平,为临床用药提供依据。方法：服用VPA治疗的癫痫患儿437例,采用均相酶放大免疫检测技术（EMIT）监测血VPA浓度,分析年龄、性别等因素对血VPA浓度的影响以及血VPA浓度与疗效之间的关系。结果：359例（82.2%）患儿血VPA浓度在有效浓度范围内（50-100μg/m L）;51例（11.7%）〈50μg/m L;27例（6.2%）〉100μg/m L。年龄、性别对血VPA浓度的影响无统计学差异（均P〉0.05）,血VPA 50-100μg/m L组的疗效与〈50μg/m L组比较,有统计学差异（χ-2=55.10,P〈0.05）。结论：癫痫患儿血VPA水平对临床用药具有重要参考意义。

Objective：To provide references for clinical drug administration by analyzing the serum concentrations of valproic acid （VPA） in pediatric epilepsy. Methods： Enyme-mutiplied immunoassay technique （EMIT） was used to detect the serum concentrations of VPA in 437 pediatric epilepsy patients. The impact of age and sex on the serum concentrations of VPA and the relation between the serum concentrations of VPA and therapeutic effect were analyzed. Results： Among the serum concentrations of VPA in 437 cases, 51 cases（11.7%） were lower than 50μg/mL; 359 cases（82.2%） between 50 and 100 μg/mL; 27 cases（ 6.2%） higher than 100 μg/mL. The impact of age and sex on the serum concentrations of VPA had no statistical difference （P〉0.05）, while the therapeutic effect be-tween 50-100 μg/mL group and 〈50 μg/mL group had statistical difference （χ2=55.10, P〈0.05）. Conclusion： The monitoring of VPA will be great important reference to drug administration for pediatric epilepsy patients.