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进展期食管癌术前新辅助放化疗的意义 被引量:4

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摘要 食管癌是目前最难治、预后最差的恶性肿瘤之一,居世界癌症死因第7位,中国癌症死因第4位.手术普遍认为是根治食管癌最主要的手段,部分早期食管癌通过手术可以治愈,但进展期食管癌单纯手术的疗效有限,多年来其5年生存率仅10%~20%.食管周围有心脏、肺、大血管等重要器官,食管本身也是人体必不可少的重要结构,使进展期食管癌较难彻底手术切除,而且常在治疗前即存在难以发现的微转移病变,单纯手术即使切除了肿瘤,也有较高的局部和远处失败.如不选择手术,放疗及化疗只能作为一种姑息的治疗手段,单纯的化疗甚至无任何益处.放疗和化疗同期联合是目前许多肿瘤有效的治疗模式,研究显示同步放化疗优于高剂量单纯放疗,但同步放化疗组局部复发率高达47%[1].
作者 何潇 郑远达
出处 《浙江临床医学》 2015年第12期2207-2209,共3页 Zhejiang Clinical Medical Journal
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  • 1Cooper JS,Guo MD,Herskovic A,et al.Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01).Radiation Therapy Oncology Group. JAMA,1999,281(17):1623-1627.
  • 2Minsky B D,Pajak T F,Ginsberg RJ,et al.INT 0123 (Radiation Therapy Oncology Group 94-05) phase Ⅲ trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. Journal of Clinical Onc ology,2002,20 (5): 1167-1174.
  • 3Nygaard K,Hagen S,Hansen H S,et al.Pre-operafive radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer. World journal of surgery,1992,16(6):1104-1109.
  • 4Apinop C,Puttisak P,Preecha N.A prospective study of combined therapy in esophageal cancer. Hepato-gastroenterology,1994,41(4):391-393.
  • 5i Pfise E L,Etienne P L,Meunier B,et al.A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous ceU carcinoma of the esophag'us.Cancer,1994,73(7):1779-1784.
  • 6Bosset J F, Gignoux M, Triboulet J p, et al.Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. New England Journal of Medicine,1997,337(3):161-167.
  • 7Urba S G,Orringer M B,Turrisi A,et al.Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. Journal of Clinical Oncology,2001,19 (2) :305-313.
  • 8Walsh T N,Noonan N,HoUywood D,et al.A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.New England Journal of Medicine,1996, 335(7):462-467.
  • 9Lee J L,Park S I,Kim S B,et al.A single institutional phase Ⅲ trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma. Annals of oncology,2004,15(6):947-954.
  • 10Burmeister B H,Smithers B M,Gebski V,et al.Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase Ⅲ trial. The lancet oncology, 2005, 6(9): 659-668.

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