摘要
目的:探讨HLA-DRB1基因多态性与系膜增生性IgA肾病(Ms PGN)的临床相关性。方法:164例IgA Ms PGN患者和164例健康受试者常规检查肾功能,采用PCR法测定HLA-DRB1基因分型,比较IgA Ms PGN患者和健康受试者的肾功能及HLA-DRB1基因分型,并且分析IgA Ms PGN患者HLA-DRB1基因分型与肾功能的关系。结果:(1)IgA Ms PGN患者和健康受试者24 h尿蛋白、血清肌酐和血清尿素氮差异具有统计学意义(P<0.01);(2)在IgA Ms PGN患者中,HLA-DRB1高频等位基因为DRB1*04、DRB1*07、DRB1*09、DRB1*11、DRB1*14和DRB1*15;(3)与健康受试者相比,DRB1*09和DRB1*11在IgA Ms PGN患者的分布频率显著升高(P<0.01或P<0.05);(4)DRB1*09和DRB1*11类型患者24 h蛋白尿、血清肌酐及血清尿素氮较HLA-DRB1其他基因类型的患者显著升高(P<0.01)。结论:HLA-DRB1基因多态性与系膜增生性IgA肾病相关,DRB1*09和DRB1*11类型可增加系膜增生性IgA肾病的风险,并且与患者肾小球肾炎严重程度有关。
Objective: To explore the clinical correlation of HLA-DRB1 shared epitope with IgA mesangial proliferative glomerulonephritis( IgA MsPGN). Methods: The renal function were examined routinely,and HLA-DRB1 shared epitope were determined by PCR in a total of 164 patients with IgA MsPGN and 164 healthy subjects. The renal function and HLA-DRB1 shared epitope were compared in patients with IgA MsPGN and healthy subjects,and clinical correlation of HLA-DRB1 shared epitope and renal function were analyzed. Results:( 1) 24 h proteinuria,serum creatinine and serum urea nitrogen were significantly different in patients with IgA MsPGN and healthy subjects( P〈0. 01);( 2) The high-frequency gene of HLA-DRB1 in patients with IgA MsPGN were DRB1 * 04,DRB1* 07,DRB1* 09,DRB1* 11,DRB1* 14 and DRB1* 15;( 3) The distribution frequency of DRB1 * 09 and DRB1 * 11 in patients with IgA MsPGN increased significantly( P〈0. 01 or P〈0. 05);( 4) 24 h proteinuria,serum creatinine and serum urea nitrogen in patients with IgA MsPGN with DRB1* 09 and DRB1* 11 were significantly different compared with those in patients with IgA MsPGN with other HLA-DRB1 shared epitope( P〈0. 01). Conclusion: HLA-DRB1 shared epitope is related to IgA MsPGN,DRB1 * 09 and DRB1* 11 can increase the risk of IgA MsPGN,and related to the severity of glomerulonephritis.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第11期1528-1531,共4页
Chinese Journal of Immunology