催产素对电刺激坐骨神经后脊髓场电位抑制作用的研究

Inhibition of oxytocin on spinal potentiation induced by electrical stimulation on peripheral nerves

目的：探讨催产素（OxT）对诱发的脊髓背角场电位的影响。方法：脊髓表面分别滴加生理盐水、微量OXT、OXT受体拮抗剂atosiban、atosibanq-OXT，坐骨神经施加强直电刺激后重复单个电刺激，观察脊髓背角诱发场电位长时程增强（I。TP）的变化。结果：①不同剂量的OXT可不同程度地抑制脊髓的场电位；（2）atosiban可明显阻断OXT对脊髓LTP的抑制效应。结论：OXT可以抑制脊髓背角的LTPOXT抑制脊髓LTP的机制可能是通过抑制OXT受体发挥作用。

Objective： To investigate the effects of Oxytocin（OXT） on spinal dorsal horn （L13 ） long-term potentiation（LTP） which is induced by peripheral stimulation. Methods：The rots were given NS and different dose OXT, Atosiban（OXT receptor antagonist）, Atosiban＋ OXT, before titanic stimu- lation. Results：Single stimulus could induce field potentials in spinal dorsal horn. The amplitude of field potentials increased after titanic stimulation , but it didn＇t increase after drops of OXT, and LTP was induced after drops of Atosiban and OXT. Conclusion~ OXT may play an inhibitory role in leaning and memory of rats; the effect may be mediated by OXT receptor.