阿尔茨海默病与癫痫
摘要
癫痫是神经系统的常见病,在老年期为第二个发病率高峰,近25%的新诊断癫痫患者为65岁以上的老人。随着年龄的增加,阿尔茨海默病(AD)的发病率增加。越来越多的证据表明AD与癫痫之间存在较为密切的联系。AD患者的癫痫发作的风险是同龄的健康人的10倍。有研究表明,AD和其他神经退行性疾病可能是10%的65岁以上老人的新诊断癫痫患者的病因,尤其是AD与非诱发性癫痫有密切联系。因此,AD可能是老年人癫痫的重要病因。
出处
《癫痫与神经电生理学杂志》
2015年第6期375-378,共4页
Journal of Epileptology and Electroneurophysiology(China)
参考文献41
-
1Ghosh S,Jehi LE. New-onset epilepsy in the elderly:challengesfor the imernist[J]. Cleve Clin J Med,2014,81(8) .490-498.
-
2Hauser WA?Morris ML,Heston LL,et al. Seizures and myoc-lonus in patients with Alzheimer,s disease [J]. Neurology,1986,36(9):1226-1230.
-
3Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsyand unprovoked seizures in Rochester, Minnesota: 1935-1984[J]. Epilepsia,1993,34(3) :453-468.
-
4Friedman D,Honig LS, Scarmeas N. Seizures and epilepsy inAlzheimer’s disease [J]. CNS Neurosci Ther, 2012, 18(4):285-294.
-
5Pandis D,Scarmeas N. Seizures in Alzheimer disease : Clinical andepidemiological data[J], Epilepsy Curr,2012,12(5) . 184-187.
-
6Rao SC, Dove G,Cascino GD, et al. Recurrent seizures in pa-tients with dementia: Frequency, seizure types, and treatmentoutcome [J], Epilepsy Behav,2009,14(1) : 118-120.
-
7McVicker RW, Shanks OE, McClelland RJ. Prevalence and as-sociated features of epilepsy in adults with Down’s syndrome[J]. Br J Psychiatry,1994,164(4) :528-532.
-
8Sherzai D?Losey T,Vega S,et al. Seizures and dementia in theelderly:Nationwide inpatient sample 1999-2008 J[J]. EpilepsyBehav,2014,36:53-56.
-
9Bernardi S?Scaldaferri N ? Vanacore N,et al. Seizures in Alzhei-mer’s disease: A retrospective study of a cohort of outpatients[J]. Epileptic Disord,2010,12(1) : 16-21.
-
10Bloechliger M,Ruegg S Jick SS,et al. Antipsychotic drug Useand the risk of seizures:Follow-up Study with a nested Case-Contral analysis[J]. CNS Drug,2015,29(7) ;591-603.
-
1陈文备,王为.反射性癫癎7例临床分析[J].中国实用内科杂志,2004,24(2):105-105.
-
2张艳影,石振东,晋红丽.青年脑梗死的危险因素、临床特点及预后分析[J].中国冶金工业医学杂志,2012,29(2):240-241. 被引量:2
-
3杨风彩,秦玉瀚,景秋玲,孙丽,冯书贵.淀粉样脑血管病并发脑出血20例临床观察[J].中国实用医药,2013,8(29):51-52. 被引量:2
-
4吕传真.糖尿病患者谨防卒中[J].家庭用药,2005(12):6-7.
-
5韦锦文,欧阳杏娟,谈琳,袁平.万拉法新与阿米替林治疗老年抑郁症对照研究[J].贵州医药,2004,28(7):657-657.
-
6王临娟.肝性脊髓病三例报告[J].实用医技杂志,2005,12(01A):97-98.
-
7田新姿.小儿诱发性癫痫病因与防治[J].河南医药信息,2001,9(4):31-32.
-
8王桂霞,王小康.内脏感觉诱发性癫1例[J].中国实用儿科杂志,2005,20(2):92-92.
-
9杨保国.小儿反射性癫痫13例分析[J].中国优生与遗传杂志,1994,2(3):125-126.
-
10解读新的癫痫临床实用性定义[J].中华医学信息导报,2014,0(17):9-9.