舍曲林联合小剂量齐拉西酮治疗强迫症

Efficacy of Seculin combined with low-dose ziprasidone on obsessive-compulsive disorder

目的 探讨舍曲林联合小剂量齐拉西酮治疗强迫症的效果. 方法 选取2012 年1 月至2014年12月强迫症患者60例,随机分为两组,对照组应用舍曲林治疗;观察组应用舍曲林联合小剂量齐拉西酮治疗. 比较两组疗效. 结果 对照组总有效率为60.0%,观察组为83.3%,两组比较差异有统计学意义（P〈0.05）;观察组治疗4、6、8周的Y-BOCS评分优于对照组,差异有统计学意义（P〈0.05）. 结论 在强迫症患者的临床治疗过程中,应用舍曲林联合小剂量齐拉西酮开展治疗具有良好的临床治疗效果与安全性,值得临床推广应用.

Objective To investigate the efficacy of Seculin combined with low-dose ziprasidone on obsessive-com-pulsive disorder.Methods From January 2012 to December 2014, 60 patients with obsessive-compulsive disorder were selected, and they were randomly divided into two groups , the control group was given sertraline , while the observation group was given sertraline combined with a small dose of ziprasidone , the clinical effects were analyzed .Results The total effective rate was 60.0%in the control group ,while that was 83.3%in the observation group , the difference was signifi-cant（ P〈0.05）;the 4, 6, 8 week treatment of Y-BOCS score in the observation group were better than those in the control group, the differences were significant（P〈0.05）.Conclusions In the clinical treatment of patients with obsessive-com-pulsive disorder , the application of sertraline in combination with low-dose ziprasidone treatment has good clinical effect and safety, so it is worthy of application.