IL1B基因多态性与儿童期创伤交互作用对抗抑郁剂疗效的影响

Influence of interleukin-1 beta gene polymorphism and childhood maltreatment on antidepressant treatment

目的探讨白介素1-1a（interleukin-1 beta，／L1B）基因启动子区rs16944位点基因多态性与儿童期创伤的交互作用对抗抑郁剂疗效的影响。方法对204例抑郁症患者进行8周心理精神量表评估随访。应用Snapshot检测儿1B基因位点rs16944单核苷酸多态性。应用Unphased3．0．13软件包分析rs16944多态性与抗抑郁疗效关联性，Logistic回归分析基因一环境交互作用对抗抑郁药物疗效的影响。结果8周治愈组与未治愈组间性别、年龄、教育程度、家族史、发病次数、HAMD-17项基线及用药情况差异均无统计学意义。药物基因关联分析表明IL1B基因rs16944位点AA基因型携带者疗效较差（x^2=3．931，P=0．047）。两患者组间儿童期创伤经历问卷总分差异无统计学意义。基因和环境交互分析发现rs16944位点AA基因型与儿童期创伤相互作用及较差的抗抑郁剂疗效相关（P=0．043）。结论IL1B基因rs16944位点多态性与儿童期创伤相互作用可能影响抑郁患者临床疗效。

Objective To explore the influence of interleukiml beta （IL1B） gene polymorphism and childhood maltreatment on antidepressant treatment. Methods Two hundred and four patients with major depressive disorder （MDD） have received treatment with single antidepressant drugs and were followed up for 8 weeks. Hamilton depression scale-17 （HAMD-17） was used to evaluate the severity of depressive symptoms and therapeutic effect. Childhood maltreatment was assessed using Childhood Trauma Questionnaire, a 28-item Short Form （CTQ-SF）. Single nucleotide polymorphism （SNP） of the ILIB gene was determined using a SNaPshot method. Correlation of rs16944 gene polymorphism with response to treatment was analyzed using Unphased 3. 0. 13 software. The main and interactive effects of SNP and childhood maltreatment on the antidepressant treatment were analyzed using Logistic regression ana].ysis. Results No significant difference of gender, age, year of education, family history, episode time, and antidepressant agents was detected between the remitters and non-remitters. Association analysis has found that the SNP rs16944 in the IL1B AA genotype carriers antidepressant response was poorer （x^2 = 3. 931, P=0. 047）. No significant difference was detected in the CTQ scores between the two groups. Genetic and environmental interaction analysis has demonstrated a significant correlation between rs16944 AA genotype and childhood maltreatment and poorer response to antidepressant treatment. Conclusion The SNP rs16944 in the IL1B gene and its interaction with childhood maltreatment may influence the effect of antidepressant treatment for patients with MDD.