充血性心力衰竭与心肌肌钙蛋白T含量变化的相关性研究

Study on the Correlation Between Congestive Heart Failure and Level of Cardiac Troponin T

目的研究充血性心力衰竭患者(CHF)病人血清心肌肌钙蛋白T(cTNT)升高与否,以及探讨升高程度与心衰严重程度之间的关系。方法该研究选取该院2012年3月—2014年4月期间在该院接受住院治疗的充血性心力衰竭患者65例为研究对象,选择同期门诊体检的健康患者65例为对照组,通过运用电化学发光免疫分析法进行测定。结果两组患者在性别、年龄、学历等人口学特征上均不存在差异,发现研究组cTNI浓度高达(0.172±0.062)ng/mL,而对照组浓度仅为(0.003±0.001)ng/mL,经过统计学分析发现差异有统计学意义。左心室射血分数(LVEF)与CHF患者cTNT浓度之间存在负相关关系(r=-0.482,P<0.01)。结论 CHF患者中血清cTNT浓度会出现较为明显的升高,升高程度与心衰的严重程度相一致,临床中可以根据CHF患者危险性分层现象开展针对性的治疗措施,在临床治疗中具有指导意义。

Objective To study whether the level of cardiac troponin T（cTNT） increases in patients with congestive heart failure（CHF） and the correlation between it and the severity of CHF.Methods 65 cases with CHF underwent hospitalization in our hospital from March 2012 to April 2014 were selected as the subjects and other 65 healthy people underwent clinic physical examination during the same period were selected as the control group.And electrochemiluminescence immunoassay was used to measure the level of cTNT in all the subjects in the two groups.Results There were no differences in gender,age,education and other demographic characteristics between the two groups.The level of cTNT of the study group was as high as 0.172±0.062ng/ml,while that of the control group was only 0.003±0.001ng/ml,the difference between the two groups was statistically significant.The left ventricular ejection fraction（LVEF） was negatively correlated with the cTNT concentration in the CHF patients（r=-0.482,P〈0.01）.Conclusion The concentration of serum cTNT in CHF patients will appear obvious rise,and its degree of elevation is consistent with the severity of heart failure.Targeted treatment based on the risk stratification phenomenon in CHF patients is of guiding significance in clinical treatment.