曲美他嗪与硝酸异山梨酯治疗稳定性劳力型心绞痛效果比较

Comparison between Trimetazidine and Isosorbide dinitrate for Stable Angina Pectoris

目的探析曲美他嗪与硝酸异山梨酯治疗稳定性劳力型心绞痛效果。方法整群选取该院2012年1月—2014年11月收治的78例稳定性劳力型心绞痛患者,对其临床资料进行回顾性分析,并在患者及家属知情同意的情况下将其分为治疗组和对照组,治疗组给予曲美他嗪,对照组给予硝酸异山梨酯,对比分析两组患者的治疗有效率及患者恢复情况。结果经治疗后,治疗组患者的有效率为97.46%,对照组患者的有效率为84.62%,两者相比较差异显著,P<0.05有统计学意义;两组患者的各项临床指标均有所改善,且治疗组显著优于对照组,P<0.05有统计学意义;治疗组患者的不良反应发生率为7.69%,对照组不良反应反生率为17.95%,两组比较差异有统计学意义(P<0.05)。结论曲美他嗪与硝酸异山梨酯治疗稳定性劳力型心绞痛都有较好的效果,但曲美他嗪能够更好的改善患者心肌缺血的症状,且患者耐受性好,值得应用。

Objective To investigate the effects of Trimetazidine and Tsosorbide dinitrate in the treatment of stable exertional angina.Methods Clinical data of 78 patients with stable angina pectoris admitted in our hospital between January 2012 and November 2014 were retrospectively analyzed,and the patients were divided into the treatment group and the control group with the their family＇s permission.Trimetazidine was used in the treatment group,while isosorbide dinitrate was used in the control group.Effective rate of treatment and recovery condition were compared between the two groups.Results After treatment,effective rate was 97.46%in the treatment group,and 84.62%in the control group,and the differences between the two groups had statistical significance（P〈0.05）;Clinical indexes in the two groups were better,and they in the treatment group were better than in the control group and the differences were statistically significant（P〈0.05）;The incidence of adverse reactions was 7.69%in the treatment group,while 17.95%in the control group,and the differences were statistically significant（P〈0.05）.Conclusion Good effects can be found both in Trimetazidine and Isosorbide dinitrate in the treatment of stable exertional angina.Trimetazidine with the function of alleviating myocardial ischemia and better tolerance is more recommenable for clinical application.