自噬对肿瘤细胞能量代谢调控的研究进展

Research Progress of Autophagy on Regulation of Energy Metabolism in Tumor Cells

目的总结近年来自噬参与肿瘤细胞能量代谢关系的最新研究进展。方法主要根据Pub Med检索相关资料,就近年来关于自噬对肿瘤细胞能量代谢调控机理以及对肿瘤生物学效应影响的最新研究进展进行综述。结果自噬能够通过对肿瘤细胞葡萄糖摄取、糖酵解途径、氧化磷酸化以及脂代谢和氨基酸代谢进行调控,从而使肿瘤的生物学行为发生改变。结论自噬对肿瘤能量代谢的调控为肿瘤在应激条件下的存活机制提供了理论依据。加深自噬对肿瘤能量代谢的调控机制以及对肿瘤生物学行为影响的研究有助于开发新的、更有效的个性化的抗癌疗法。就自噬对肿瘤能量代谢研究进展来看,我们必须揭示清楚的是自噬对肿瘤能量代谢调控是否与癌基因、抑癌基因、信号通路等其他因素有关,以及对不同类型肿瘤生物学行为产生何种影响。

Objective To summarize the latest research progress of autophagy on regulation of tumor energy metabolism. Method The latest research progresses of the regulation mechanism of autophagy on the energy metabolism of tumor cells and the influence on the biologic behavior of tumor in recent years were reviewed. Result The autophagy could affect the biological behavior of the tumor by influence of the tumor cell glucose uptake, glycolysis, oxidative phosphorylation, lipid metabolism, and amino acid metabolism. Conclusions The regulation of autophagy on tumor energy metabolism provides a theoretical basis for the survival mechanism of tumor under the stress condition. What＇s more, to research the mechanism of autophagy on regulation of energy metabolism and the effect on tumor biologic behavior will contribute to the development of new and more effective personalized anticancer therapy. As far as the research progress about tumor ceils energy metabolism regulated by autophagy, what we must be revealed is whether other factors including oncogene, anti-oncogene, and signaling pathways take part in this regulation and what influence would be on the biological behavior of different tumors.