摘要
Sestrins由应激诱导产生,是在进化上相对保守的蛋白家族,能抑制氧化应激、调节腺苷酸活化蛋白激酶(AMPK)-哺乳动物雷帕霉素作用靶点(m TOR)通路来保护细胞和器官免受应激、老化带来的生理损伤。低氧、缺乏ATP可诱导Sesn2的表达。Sestrin在血糖稳态调节方面意义重大。Sestrins也参与延缓衰老、抑制年龄相关性疾病。
Sestrins constitue the protein family which are evolutionarily consvered and stress inducible,they suppress the oxidative stress and regulate adenosine monophosphate-dependent protein kinase （AMPK）-mammalian target of rapamycin （mTOR） signaling and protect cells and organisms from stress and age-related physiological abnormalities. Hypoxia and ATP deficiency induce Sesn2 expression. Sestrins regulation of blood sugar homeostasis is physiologically impotant. Sestrins also contribute to the protection against of aging and suppression of age-associated diseases.
出处
《基础医学与临床》
CSCD
2015年第12期1677-1681,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81270251)
