七水三氯化铈-碘化钠/二氧化硅-壳聚糖催化剂的制备及其在脱保护反应中的应用

Preparation of Silica/Chitosan Supported Cerium(Ⅲ)Chloride Heptahydrate-Sodium Iodide and Its Application on the Cleavage of t-Butyl Ether and Dithioacetal

分别以Y沸石、活性碳和二氧化硅-壳聚糖(Si O_2-CS)为载体、利用浸渍法制备了一系列负载型七水三氯化铈-碘化钠(Ce Cl_3·7H_2O-Na I)催化剂,考察了它们在叔丁基苯基醚的脱保护反应中的催化性能。结果表明,Si O_2-CS为载体的催化剂呈现出良好的催化性能和较高的稳定性。另外,在中性条件下,Si O_2-CS负载Ce Cl_3·7H_2O-Na I催化剂在叔丁基醚及1,3-二硫缩醛脱保护反应中呈现出较高的催化活性,从而避免使用强酸和强碱。

A series of CeCl3·7H2O/NaI catalysts immobilized on various supports such as Y zeolite, activated carbon, and SiO2-CS was prepared. Their catalytic performances were evaluated in the deprotection reactions of tert-butyl phenyl ether. The supported catalyst exhibits good stability and catalytic activity. To further investigate the application of SiO2-CS-CeCl3·7H2O/NaI system in other deprotection reactions, t-butyl ether and 1,3-dithioacetals were explored. In neutral conditions, the catalyst can effectively promote the deprotection reaction, and the use of strong acid and strong base can be avoided.