脑性瘫痪基因研究进展

Research progress of genes of cerebral palsy

脑性瘫痪（脑瘫）是一组持续存在的中枢性运动和姿势发育性障碍、活动受限症候群，是造成儿童肢体残疾的主要疾病，对社会和家庭造成严重影响。国内外研究表明，其易感性与遗传因素有关。国内外初步研究证明，脑瘫发生与多个易感基因有关，脑瘫症状基因与脑瘫的临床症状有密切联系。现就近年来有关脑瘫的易感基因和症状基因的研究进展进行综述。

Cerebral palsy （CP） is the most common activity limitition of children,their movement and posture impairments persist throughout whole life. In recent years, CP has been significantly increasing with the improved survival rate of newborns. This may lead to a great burden and costs to both the family and the society. A variety of risk factors have been proposed to be associated with CP. However,recent abroad researches indicate that genetic factors may predispose to CP of newborns and initial results of related researches infer that several susceptibility genes may contribute to CP＇s development, masqueraders have a great impact on CP＇s clinical symptoms. Now, the recent publications related to virulence genes and masqueraders of CP are reviewed.