摘要
目的运用动态血压监测方法观察比较不同时间药物干预对高血压患者血压晨峰的临床效果。方法 2009年1月至2012年4月期间深圳市宝安区人民医院经动态血压检测明确有血压晨峰现象的120例原发性高血压患者作为研究对象,所有患者服用氯沙坦50 mg,按服药时间不同随机分为两组:A组(每日清晨服药1次)和B组(每日睡前服药1次),两组用药2周后再行24 h动态血压监测,记录患者觉醒后2 h的平均收缩压(MSBP)、平均舒张压(MDBP)、最高收缩压(MAXSBP)及最高舒张压(MAXDBP),比较用药前后血压的变化情况。结果两组用药前后MSBP、MDBP、MAXSBP、MAXDBP差异均具有统计学意义(P<0.05);其中A组用药后MSBP平均下降(16.9±8.5)mm Hg,B组MSBP平均下降(20.5±9.3)mm Hg,两者比较差异有统计学意义(P<0.05);A组用药后MDBP平均下降(5.4±5.9)mm Hg,B组MDBP平均下降(6.7±6.3)mm Hg,两者比较差异无统计学意义(P>0.05)。结论晨起或睡前服用氯沙坦均能降低高血压晨峰患者在清晨醒后的血压水平,其中睡前服用氯沙坦能更有效的降低醒后的收缩压水平。
Objective To investigate the clinical effect of chronotherapeutics on morning blood pressure surge in patientswith hypertension. Methods 120 patients certified of hypertension morning surge by ABPM with hypertension from Jan.2009 to Apr.2012 in Baoan peoples' hospital were included in this study.All the patients receiving losartan 50 mg were randomly assigned into groups A and B according to different time formedication : patients in group A were taken medicine atawakening time and patients in group B were taken medicine before sleeping time. Blood pressure changes were compared after 2 weeks treatment according tomean systolic blood pressure(MSBP), mean diastolic blood pressure(MDBP), maximal systolic blood pressure(MAXSBP), and maximal diastolic blood pressure(MAXDBP)after awakening 2 hours. Results The MSBP / MDBP / MAXSBP / MAXDBP changes before and after taken medicine in group A or B were all significantly different(P〈0.05). The MSBP of group A dropped(16.9±8.5) mm Hg in average,and the MSBP of group B dropped(20.5±9.3) mm Hg in average; there was significant difference(P〈0.05). The MDBP of group A dropped(5.4±5.9) mm Hg in average, and the MDBP of group B dropped(6.7 ±6.3) mm Hg in average; there was no significant difference(P〈0.05). Conclusion Taken losartan at awakening time or at sleeping time were able to control hypertension morningsurge, and taken losartan at sleepingtime was better on control systolic blood pressure.
出处
《热带医学杂志》
CAS
2015年第11期1495-1498,共4页
Journal of Tropical Medicine
关键词
高血压
高血压晨峰
氯沙坦
疗效差异
Hypertension
Morning blood pressure surge
Losartan
Clinical effect