米索前列醇不同给药方式联合缩宫素对足月妊娠产妇的影响

Analysis of the effect of different administration methods combined with oxytocin on full-term pregnant women

目的研究米索前列醇不同给药方式联合缩宫素对足月妊娠产妇血钙、纤维蛋白原(FIB)、D-二聚体水平的影响及产后出血的预防。方法选择2012年6月至2014年5月期间我院收治的住院分娩的晚期孕妇180例为研究对象,随机分成A、B、C 3组,每组各60例,A组给予米索前列醇直肠给药联合缩宫素静脉推注,B组给予米索前列醇舌下含服给药联合缩宫素静脉推注,C组只给予单纯缩宫素静脉推注。观察并仔细记录3组产妇血钙、FIB、D-二聚体水平以及产后24 h出血量、记录3组患者的不良反应。结果产妇血钙、FIB、D-二聚体水平A组与B组相比均无明显差异,C组FIB低于A、B组,D-二聚体高于A、B组,差异有统计学意义(P<0.05);3组产妇2 h、24 h出血量,A组与B组相比均无明显差异,C组与A、B组相比出血量较多,两组数据比较差异有统计学意义(P<0.05)。结论米索前列醇联合缩宫素对足月妊娠产妇血钙影响不明显,对FIB、D-二聚体水平影响明显,同时预防产后出血疗效显著,不同给药方式对预防产后出血效果相似。

Objective To study the effect of different ways of administration of misoprostol combined with oxytocin on full-term pregnancy maternal serum calcium,fibrinogen（FIB）,D2 polymer levels and the prevention of postpartum hemorrhage analysis. Methods 180 cases of late pregnant women of our hospital from June 2012 to May 2014 were selected for this study, and were randomly divided into group A,B and C,60 cases in each group. The treatment group 1received misoprostol rectal administration combined with oxytocin intravenous injection; group B was given misoprostol sublingually administered combined with oxytocin intravenous injection, while the control group was only given simple oxytocin intravenous injection. The levels of serum calcium, FIB and D2 polymer, 24 h post partum bleeding volume and adverse reactions of three groups of patients were recorded. Results The maternal serum calcium, FIB, two D2 polymer levels in treatment group A and B showed no significant differences, but were significantly different from those of the control group. The bleeding volumes at 2 h and 24 h of group A and B had no significant differences, but were significantly less than that of group C. Conclusion Misoprostol combined with oxytocin in full-term pregnant women had no obvious effect on serum calcium, FIB, D2 polymer levels, and might prevent postpartum hemorrhage. Different administration methods on preventing postpartum hemorrhage had similar effect.