股骨头缺血性坏死动物模型制备的研究进展

RESEARCH PROGRESS OF EXPERIMENTAL ANIMAL MODELS OF AVASCULAR NECROSIS OF FEMORAL HEAD

目的总结股骨头缺血性坏死动物模型制备的研究现状及进展。方法查阅国内外有关股骨头缺血性坏死动物模型制备方法的相关文献,并进行总结分析。结果目前股骨头缺血性坏死动物模型制备方法分为创伤性及非创伤性两类,其中创伤性包括外科手术、物理损伤、化学损伤,非创伤性包括激素、脂多糖、激素联合脂多糖、激素联合马血清等。各种造模方法均有优缺点,尚无一种理想的造模方法。结论股骨头缺血性坏死动物模型制备方法较多,需根据研究目的进行选择,理想的股骨头缺血性坏死动物模型制备方法有待进一步探索研究。

Objective To summarize the current researches and progress on experimental animal models of avascular necrosis of the femoral head. Methods Domestic and international literature concerning experimental animal models of avascular necrosis of the femoral head was reviewed and analyzed. Results The methods to prepare the experimental animal models of avascular necrosis of the femoral head can be mainly concluded as traumatic methods （including surgical, physical, and chemical insult）, and non-traumatic methods （including steroid, lipopolysaccharide, steroid combined with lipopolysaccharide, steroid combined with horse serum, etc）. Each method has both merits and demerits, yet no ideal methods have been developed. Conclusion There are many methods to prepare the experimental animal models of avascular necrosis of the femoral head, but proper model should be selected based on the aim of research. The establishment of ideal experimental animal models needs further research in future.