Tyrer-Cuzick模型结合超声影像评估乳痛患者乳腺癌患病风险的研究

Evaluation of Tyrer-Cuzick model and ultrasonic image for breast cancer risk assessment in patients with mastalgia

目的通过比较乳腺疼痛患者和正常体检者的乳腺癌风险及超声结果探讨乳腺疼痛与乳腺癌的关系。方法收集83例周期性乳痛患者(A组)、40例非周期性乳痛患者(B组)和100例体检对照者(C组)的相关临床资料,比较三组间的乳腺癌Tyrer-Cuzick模型预测风险及超声分类结果。结果周期性乳痛患者,非周期性乳痛患者及正常体检者在年龄、身高、体重、BMI、初次生育年龄、初潮年龄、初育至初潮时间间隔、乳腺癌10年预测风险、终身风险及超声检查分类方面没有统计学差异。结论乳痛并不是乳腺癌的早期症状,不增加乳腺癌发病风险。

Objective To investigate the possible association between mastalgia and breast cancer risk by Tyrer-Cuzick model and ultrasonic image.Methods 83 women with cyclic mastalgia（group A）,40 women with non-cyclic mastalgia（group B）and 100 normal controls（group C）were enrolled in this study.The related clinical data of all patients were collected and were compared with Tyrer-Cuzick model for breast cancer risk assessment.The ultrasonic grading results were compared between the groups and evaluated for breast cancer risk prediction.Results There was no significant difference between the three groups in age,height,weight,BMI,age at first birth,age at menarche,intervals between menarche and first birth,the risk of developing breast cancer in 10 years,the lifetime risk of developing breast cancer,and ultrasonic grading results.Conclusion Mastalgia is not one of the early symptoms of breast cancer,and will not increase the risk of breast cancer.