强脉冲光自动脉冲技术联合氨甲环酸治疗黄褐斑60例临床观察

Clinical Observation of Intense Pulsed Light with Automatic-pulse Technology Combined with Tranexamic Acid in Treating 60 Cases of Melasma

目的评价强脉冲光自动脉冲技术（automatic—pulsetechnology，APT）联合氨甲环酸治疗黄褐斑的疗效和安全性。方法将入选的180例黄褐斑患者随机分为三组，各60例，治疗组接受APT联合氨甲环酸治疗，对照1组仅接受APT治疗，对照2组仅接受氨甲环酸治疗。APT治疗1坎／月，5～6次为1个疗程，氨甲环酸胶囊口服，250mg／次，2次／d，疗程6～9个月。疗程结束后6个月比较三组患者的临床疗效及安全性。结果治疗组、对照1组和对照2组有效率分别为75．86％，20．34％和43．64％，三组间疗效差异有统计学意义（P〈0．05）。三组均有个别病例出现轻微不良反应，但均可耐受。结论AP，r联合氨甲环酸治疗黄褐斑可获得较好的临床疗效和安全性，疗效优于单用APT或单用氨甲环酸。

Objective To evaluate the efficacy and safety of intense pulsed light with automatic-pulse technology （APT） combined with tranexamie acid in the treatment of melasma. Methods One hundred and eighty pa- tients with melasma were randomly divided into three groups. Sixty patients （ control group 1 ） were treated with APT once a month for 5 to 6 times. Sixty patients （ control group 2 ） were treated with tranexamic acid capsule 250rag,two times per day for 6 to 9 months. And 60 patients （treatment group） were treated with APT combined with tranexamic acid. The efficacy and safety were assessed at 6 months post-treat- ment. Results The effective rates in treatment group, control group 1 and control group 2 were 75.86%, 20. 34% and 43.64%, respectively （P 〈 0. 05, between the groups）. Minor adverse events occurred in three groups. Conclusion APT combined with tranexamic acid is more effective than APT or tranexamic acid a- lone for melisma, and safe.