外用卤米松乳膏联合高能UV治疗白癜风25例临床疗效分析

Clinical Efficacy of Topical Halometasone Combined with High-Energy UV for 25 Cases of Vitiligo

目的探讨外用卤米松乳膏联合高能紫外线(ultraviolet,UV)治疗白癜风的临床疗效及安全性。方法50例稳定期寻常型白癜风患者随机、开放分为两组,治疗组25例予0.05%卤米松乳膏,同时给予高能UV;对照组25例予0.03%他克莫司软膏,同时予高能UV。所有患者治疗12周。结果治疗4周后治疗组及对照组的有效率及显效率差异均无统计学意义(P>0.05);8周后两组有效率差异有统计学意义(P<0.05),显效率差异无统计学意义(P>0.05);12周后治疗组及对照组的有效率及显效率差异均无统计学意义(P>0.05)。结论外用卤米松乳膏或他克莫司软膏联合高能UV均可以安全有效的治疗白癜风,前者起效更快。

Objective To evaluate the efficacy and safety of halometasone combined with high-energy ultraviolet（UV） for vitiligo. Methods A randomized, open-label study was performed in 50 non-segmental vitiligo patients with stablelesions. In the treatment group, 25 patients were treated with topical 0. 05% halometasone cream com- bined with high-energy UV for 12 weeks. Twenty-five patients treated with topical 0. 03% tacrolimus ointment combined with high-energy UV served as controls. Results After 4 weeks of treatment,the effective rates were no significant differences between the two groups （ P 〉 0. 05 ）. After 8 weeks of treatment, the improvement rates were significant differences between the two groups （ P 〈 0. 05 ）, but the markedly improved rates were similar between the two groups（ P 〉 0. 05 ）. After 12 weeks of treatment, again the effective rates were no significant differences between the two groups （ P 〉 0. 05 ） . Conclusion Both therapies are effective for vitili- go. Halometasone combined with high-energy UV induces a more rapid response.