复方扶芳藤合剂对D-半乳糖衰老模型小鼠抗氧化能力的影响

Effects of compound Fufangteng Mixture on antioxidation capacity of aged model mice induced by D-galactose

目的:研究复方扶芳藤合剂对D-半乳糖衰老模型小鼠体内抗氧化能力的影响。方法:将72只小鼠随机分为正常组、模型组、Vit E阳性对照组、复方扶芳藤合剂低、中、高剂量组。连续给药灌胃8周后,检测脑、肾、心组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性和丙二醛(MDA)含量及脑组织中总抗氧化能力(T-AOC)等抗氧化相关指标。结果:复方扶芳藤合剂可以显著降低丙二醛含量,提高超氧化物歧化酶、谷胱甘肽过氧化物酶的活力,并增强脑组织的总抗氧化能力。结论:复方扶芳藤合剂可以提高D-半乳糖衰老模型小鼠的抗氧化能力。

OBJECTIVE To study effects of compound Fufangteng Mixture （FFH） on antioxidation capacity of aged model mice induced by D-galactose. METHODS Seventy-two mice were randomly divided into six groups： normal control group, ag- ing model group, vitamin E positive control group, high, middle and low dose FFH groups. Activities of superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） contents were determined in brain, kidney and hearttissues after medication for eight weeks. Total antioxidant capacity （T AOC） in brain tissue was also collected. RESULTS FFHcould significantly improve activities of SOD, GSH-Px and T-AOC and decrease content of MDA. CONCLUSION CompoundFufangteng Mixture can enhance antioxidant capacity of aged model mice induced by D-galactose.