66例老年女性乳腺癌患者的临床分析

Clinical Research of the 66 Elderly Female Breast Cancer Patients

目的:探讨老年女性乳腺癌的临床特征及预后因素。方法:回顾性分析66例70岁以上年女性乳腺癌患者的临床资料及治疗效果。结果:全组患者1年生存率为100%,3年生存率为82.2%,5年生存率为73.0%。单因素分析显示,肿瘤分期、淋巴结转移、病理分子分型、有无手术和内分泌治疗是影响老年乳腺癌患者预后的主要因素。Cox多因素分析显示,肿瘤分期、淋巴结转移和有无手术是影响预后的独立因素。结论:老年女性乳腺癌具有独特的生物学特点,ER、PR阳性表达率高,肿瘤分期及淋巴结转移是影响预后的主要因素,所以早发现、早治疗可提高生存率。病理类型主要为浸润性导管癌,治疗应选择以手术为主的综合治疗,其中内分泌治疗占重要地位。

Objective：To evaluate the clinical features and prognostic factors of elderly female breast cancer pa-tients. Methods：The clinical data and treatment effects of 66 cases of female breast cancer patients over the age of 70 years were retrospectively analysized. Results：In the whole group,the 1-year survival rate was 100% ;3-year survival rate was 82. 2% ;and the 5-year survival rate was 73% . Univariate analysis showed that the factors,tumor pathology staging,lymph node metastasis,molecular typing,surgery and hormonal treatment ,were the keys to influencing the prognosis of elderly patients with breast cancer. Cox multivariate analysis showed that staging,lymph node metastases and surgery were independent prognostic factors. Conclusions：Elderly women Patients with breast cancer involve u-nique biological characteristics. They have higher frequency of ER and PR positivity,tumor stage and lymph node me-tastasis,which are the main prognostic factors. Therefore,early detection and early treatment can improve survival. The main pathological type is primary invasive ductal carcinoma. Surgery should be chosen as the main method of combined treatment,in which hormone therapy plays an important role.