中轴型脊柱关节炎患者生存质量评估及影响因素分析

Evaluation of life quality of patients with axial spondyloarthritis and analysis of influencing factors

目的评估中轴型脊柱关节炎(Sp A)患者的生存质量,探讨影响中轴型Sp A患者生存质量的人口学、炎症水平、疾病活动度、功能受损度等因素。方法整群抽取213位中轴型Sp A患者,采用SF12-v2量表评估患者的生存质量,分析影响生存质量因素。结果与常模人群相比,中轴型Sp A患者的生存质量显著下降(P<0.05)。血沉正常组在SF12-v2各维度得分(除活力外)、生理总评分均较血沉升高组高(P<0.05);低疾病活动组[Bath AS疾病活动性指数(BASDAI)<4、AS病情活动度评分(ASDAS)<2.1]的SF12-v2各维度得分(除活力外)、生理总评分、心理总评分均较高疾病活动组(BASDAI≥4、ASDAS≥2.1)高(P<0.05);功能状态较好组[Bath AS疾病功能指数(BASFI)<5]的SF12-v2各维度得分(除活力外)、生理总评分、心理总评分均较功能状态较差组(BASFI≥5)高(P<0.05)。SF-12v2各维度、生理总评分、心理总评分与ASDAS、BASFI均呈显著相关(P<0.05);SF-12v2各维度、生理总评分与血沉、C反应蛋白、BASDAI、Bath AS疾病测量指数(BASMI)均呈显著相关(P<0.05)。多元线性回归显示生理总评分与ASDAS、BASFI存在线性相关。结论 AS患者的生存质量明显低于常模人群,患者生存质量与炎症水平(血沉、C反应蛋白)、疾病的活动度(BASDAI、ASDAS)、功能受损度(BASFI、BASMI)明显相关。

Objective To evaluate the life quality of patients with axial spondyloarthritis（SpA） and discuss the influencing factors in terms of demography,inflammation level,disease activity,and the degree of functional impairment.Methods A total of 213 patients with axial SpA were selected.Patients＇ quality of life was evaluated by SF12-v2 health survey and factors influencing the quality of life were analyzed.Results Compared with normal people,the quality of life of patients with axial SpA significantly decreased（P〈0.05）.Scores of all dimensions（except the vitality） of SF12-v2 and physical component summary（PCS） of the normal erythrocyte sedimentation rate（ESR） group were higher than those of increased ESR group（P〈0.05）.Scores of all dimensions（except the vitality） of SF12-v2,PCS,and mental component summary（MCS） of the low disease activity group（BASDAI〈4,ASDAS〈2.1） were higher than those of high disease activity group（BASDAI≥4,ASDAS≥2.1）（P〈0.05）.Scores of all dimensions（except the vitality） of SF12-v2,PCS,and MCS of the good functional status group（BASFI〈5） were higher than those of poor functional status group（BASFI≥5）（P〈0.05）.Scores of all dimensions of SF12-v2,PC S,and MCS were significantly correlated with ASDAS and BASFI（P〈0.05）.Scores of all dimensions of SF12-v2 and PCS were significantly correlated with ESR,CRP,BASDAI,and BASMI（P〈0.05）.Multiple linear stepwise regression analysis showed that PCS was linearly correlated with ASDAS and BASFI.Conclusion The quality of life of patients with axial SpA is markedly lower than that of normal people.The quality of life is significantly correlated with inflammation level（ESR and CRP）,disease activity（BASDAI and ASDAS）,and the degree of functional impairment（BASFI and BASMI）.