银杏叶软胶囊对缺血性中风患者血清C反应蛋白及胱抑素C的影响

Effect of Ginkgo Leaves Soft-gel Capsule on Serum C Reactive Protein and Cystatin C in Patients with Ischemic Stroke

目的:研究银杏叶软胶囊治疗缺血性中风(痰瘀证候)的疗效及对患者血清C反应蛋白及胱抑素C的影响。方法:选择2012年1月—2015年1月在医院就诊的缺血性中风急性期(痰瘀证候)患者84例作为研究对象,随机分成对照组和观察组,各42例。对照组:接受缺血性中风急性期的常规治疗。观察组:缺血性中风急性期的常规治疗,同时口服银杏叶软胶囊。比较两组患者的疗效,观察治疗前后两组患者中医证候总积分、CSS评分及BI指数的变化,观察治疗前后两组患者血脂指标TG、TC以及LDL-C水平的变化,观察治疗前后两组患者炎性指标CRP、s ICAM、P-选择素及胱抑素C水平的变化。结果:观察组总有效率为92.9%高于对照组总有效率76.2%,差异具有统计学意义(P<0.05)。治疗后,观察组中医证候总积分(26.8±5.2)分低于对照组中医证候总积分(39.0±7.6)分,差异具有统计学意义(P<0.01)。治疗后,观察组CSS评分(13.2±3.9)分低于对照组CSS评分(19.6±5.0)分,差异具有统计学意义(P<0.01)。治疗后,观察组BI指数(59.5±12.8)分高于对照组BI指数(48.2±11.7)分,差异具有统计学意义(P<0.01)。治疗后,观察组TG、TC、LDL-C水平低于对照组,差异具有统计学意义(P<0.01)。治疗后,观察组患者的CRP、s ICAM、P-选择素水平低于对照组,差异具有统计学意义(P<0.01)。结论:银杏叶软胶囊治疗缺血性中风急性期(痰瘀证候)的疗效确切,能够显著改善患者的症状、促进患者神经功能的恢复,并可有效降低机体的血脂水平、减轻局部炎症反应。

Objective： To study the curative effect of Ginkgo Leaves Soft-gel Capsule in the treatment of ischemic stroke（ phlegm and blood stasis syndrome） and the intervention of serum C reactive protein and cystatin C. Method： 84 patients with acute ischemic stroke（ phlegm and blood stasis syndrome） as the research object in 2012 January-January2015 in our hospital were randomly divided into control group and observation group,42 cases in each. The control group received routine treatment of acute ischemic stroke. The observation group： routine treatment of acute ischemic stroke and oral Ginkgo biloba soft capsule. Compare curative effect in two patients group. Before and after treatment,we observed TCM syndrome total score,CSS score and BI index changes in the two groups,patients＇ blood lipid indices,TG,TC and LDL-C levels in two groups. We observed CRP,s ICAM and P-change of P-selectin and cystatin C levels in two groups before and after treatment. Results： The total efficiency of observation group was 92. 9%,higher than that of the control group（ 76. 2%） and the difference was statistically significant（ P 〈0. 05）. After treatment,the observation group＇s TCM syndrome total score（ 26. 8 ± 5. 2） was lower than that of control group（ 39 ± 7. 6） and the difference was statistically significant（ P〈 0. 01）. After treatment,the CSS score of the observation group（ 13. 2 ± 3. 9） was lower than that of control group＇s（ 19. 6 ± 5） and the difference was statistically significant（ P〈 0. 01）. After treatment,the observation group＇s BI index（ 59. 5 ± 12. 8） was higher than the control group（ 48. 2 ± 11. 7） and the difference was statistically significant（ P〈 0. 01）. After treatment,TG,TC and LDL-C levels in the observation group were lower than the control group＇s and there was statistically significant difference（ P 〈0. 01）. After treatment,CRP,s ICAM and P-levels in the observation groupwere lower than the control group＇s and there was statistically significant difference（ P 〈0. 01）. Conclusion：Ginkgo Leaves Soft-gel Capsule treatment of acute ischemic stroke（ phlegm and blood stasis syndrome） has good curative effect and can significantly improve the symptoms of patients,promote the recovery of neural function and can effectively reduce the blood lipid level and reduce the local inflammatory reaction.