自拟兰术化浊汤治疗溃疡性结肠炎临床疗效探讨及对血清炎性细胞因子水平的影响

Clinical Efficacy Investigation of Self-Made Lanzhu Huazhuo Decoction in Treatment of Ulcerative Colitis and Influence of Serum Inflammatory Cytokine Levels

目的:探讨自拟兰术化浊汤治疗溃疡性结肠炎临床疗效及对血清炎症因子指标的影响。方法:研究对象选取医院2013年1月—2014年12月收治溃疡性结肠炎患者80例,采用随机数字表法分为对照组和治疗组,每组各40例;其中对照组患者采用奥沙拉嗪钠单用治疗;治疗组患者则在对照组基础上加用自拟兰术化浊汤治疗;比较两组患者临床疗效,治疗前后临床症状积分、炎性细胞因子指标水平及临床复发率等。结果:对照组和治疗组患者治疗总有效率分别为77.50%(31/40),95.00%(38/40);治疗组患者临床疗效显著优于对照组,差异有统计学意义(P<0.05);对照组患者治疗前后临床症状积分分别为(4.88±0.97)分,(4.06±0.73)分;治疗组患者治疗前后临床症状积分分别为(4.82±0.95)分,(3.15±0.50)分;治疗组患者治疗后临床症状积分显著低于对照组、治疗前,差异有统计学意义(P<0.05);对照组患者治疗前后TNF-α水平分别为(65.33±6.24)ng/L,(59.07±4.37)ng/L;对照组患者治疗前后IL-8水平分别为(79.64±8.62)ng/L,(68.71±6.62)ng/L;治疗组患者治疗前后TNF-α水平分别为(65.28±6.19)ng/L,(51.25±2.98)ng/L;治疗组患者治疗前后IL-8水平分别为(79.87±8.58)ng/L,(60.54±4.37)ng/L;治疗组患者治疗后炎性细胞因子指标水平显著低于对照组、治疗前,差异有统计学意义(P<0.05);对照组与治疗组患者随访复发率分别为17.50%(7/40),5.00%(2/40);治疗组患者临床复发率显著低于对照组,差异有统计学意义(P<0.05)。结论:自拟兰术化浊汤治疗溃疡性结肠炎可有效缓解临床症状体征,改善炎性因子指标水平,且有助于降低复发风险。

Objective： To investigate the clinical efficacy of self-made Lanzhu Huazhuo Decoction in the treatment of ulcerative colitis and influence of serum inflammatory cytokine levels. Methods： 80 patients with ulcerative colitis were chosen from January 2013 to December 2014 in our hospital and randomly divided into two groups including control group（ 40 patients） with olsalazine sodium used alone and treatment group（ 40 patients） with self-made Lanzhu Huazhuo Decoction on the basis of control group. And the clinical effect,clinical symptoms scores and inflammatory factor levels before and after treatment and the clinical recurrence rate of both groups were compared. Results： The clinical total effects of control group and treatment group were separately 77. 50%（ 31 /40） and 95. 00%（ 38 /40）. The clinical effects of treatment group were significantly better than the control group＇s（ P 0. 05）. The clinical symptoms scores before and after treatment of control group were separately（ 4. 88 ± 0. 97） points and（ 4. 06 ± 0. 73） points. The clinical symptoms scores before and after treatment of treatment group were separately（ 4. 82 ± 0. 95） points and（ 3. 15 ± 0. 50） points. The clinical symptoms scores of treatment group after treatment were significantly lower than that of the control group and before treatment（ P 〈0. 05）. The levels of TNF-α before and after treatment of control group were separately（ 65. 33 ± 6. 24） ng / L and（ 59. 07 ± 4. 37） ng / L. The levels of IL-8 before and after treatment of control group were separately（ 79. 64 ± 8. 62）ng / L and（ 68. 71 ± 6. 62） ng / L. The levels of TNF-α before and after treatment of treatment group were separately（ 65. 28 ± 6. 19） ng/L and（ 51. 25 ± 2. 98） ng/L. The levels of IL-8 before and after treatment of treatment group wereseparately（ 79. 87 ± 8. 58） ng / L and（ 60. 54 ± 4. 37） ng / L. The inflammatory factor levels of treatment group after treatment were significantly lower than those of the control group and before treatment（ P〈 0. 05）. The clinical recurrence rate of control group and treatment group were separately 17. 50%（ 7 /40） and 5. 00%（ 2 /40）. The clinical recurrence rate of treatment group was significantly lower than that of the control group（ P〈 0. 05）. Conclusion： Self-made Lanzhu Huazhuo Decoction in the treatment of ulcerative colitis can efficiently relieve the clinical symptoms and signs and improve the level of inflammatory factors and be helpful to reduce the risk of recurrence.