江苏泰兴农村人群牙周病与慢性肾脏病关联分析

Analysis of association between periodontal disease and chronic kidney disease among general population in rural area of Jiangsu Taixing

目的 探讨农村人群牙周病与慢性肾脏病的相关性。方法 对江苏省泰兴地区4个行政村35-65岁居民进行问卷调查、体质测量及生化检测。使用社区牙周指数评判牙周病及其严重程度,根据血清肌酐计算肾小球滤过率评价肾脏功能,采用回归分析评价牙周病与慢性肾脏病的相关性。结果 该地区人群牙周病、慢性肾脏病的患病率分别为45.3%和1.4%。单因素Logistic回归分析显示牙周病增加了慢性肾脏病的患病风险,OR及95%置信区间为2.62（1.06-6.47）。经多因素校正,牙周病与慢性肾脏病关联无统计学意义。线性回归分析结果显示,多因素校正后肾小球滤过率随着牙周病严重程度的增加而逐渐下降（P〈0.05）。结论 牙周病可能是慢性肾脏病的风险因素,需进一步开展前瞻性研究确定因果关系。

Objective To explore the association between periodontal disease and chronic kidney disease in rural general pop- ulation. Methods Residents aged 35-65 years were selected from 4 villages in Taixing,Jiangsu province, performing the question- naire investigation, physical measurements and biochemical test. The community periodontal index was used for assessing the perio- dontal disease and its severity, Renal function was assessed by the modified glomerular filtration rate estimating equation for Chi- nese, and the correlation between periodontal disease and chronic kidney disease was evaluated by regression analysis. Results The crude prevalence of periodontal disease and chronic kidfley disease were respectively 45. 3% and 1. 4%. Univariate logistic regres- sion analysis showed that the periodontal disease significantly increased the risk of chronic kidney disease,OR and 95% CI （confi- dence intervals） was 2.62 （1.06-6.47）. After revising of multiple--factors,there was no statistic significance between periodontal diseases and chronic kidney disease. The liner regression analysis showed that gtomerular filtration rate gradually decreased along with the increase of the severity of periodontal disease after multi-factor correction（P〈0. 05）, Conclusion Periodontal disease may be the risk of chronic kidney disease and prospective studies should be further developed to determine their causalities.