MKK4基因启动子区-1044A>T多态与鼻咽癌易感性的研究

Research of association between functional polymorphism(1044A>T)in the MKK4 gene and the susceptivity of nasopharyngeal carcinoma

目的 探讨MKK4基因启动子区-1044A〉T位点单核苷酸多态基因型与散发性鼻咽癌遗传易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性法（PCR-RFLP）检测30例健康人和90例鼻咽癌患者的MKK4基因-1044A〉T位点（rs3809728）单核苷酸多态性。结果 MKK4基因-1044A〉T位点基因多态性在病例组和对照组中分布差异无统计学意义,AT基因型（OR=0.726,95%CI=0.333-2.151）,TT基因型（OR=0.952,95%CI=0.094-9.663）,P=0.712。结论 MKK4基因-1044A〉T位点的单核苷酸多态性：可能与散发性鼻咽癌易感性无关。

Objective To investigate the association between the functional polymorphism（1044A〉T） of the MKK4 gene and the genetic susceptibility of sporadic nasopharyngeal carcinoma. Methods Detected the mononocletide polymorphism of MKK4 cinoma by using polymerase chain reaction-restric- gene （1044A〉T） in 30 healthy people and 90 patients with nasopharyngeal carcinoma by using polymerase chain reaction-restrietion fragment length polymorphism（PCR-RFLP） Results There was no statistical sighificance of the MKK4 gene （1044A〉T）between experimental and control group（AT： OR=0.726,95% CI, 0.333 0：094-9. 663, P =0. 712）. Conclusion Mononocletide polymorphism of MKK4 gene （1044A〉T） may not relate to the susceptibility of sporadic nasopharyngeal carcinoma.