人类免疫缺陷病毒耐药检测研究进展

Research progress of drug resistance detection of human immunodeficiency virus

艾滋病抗病毒治疗对于病毒抑制和患者生存意义重大,但病毒耐药问题的出现已成为治疗的严重威胁,不仅会导致个体治疗的失败,也会引发耐药毒株的传播风险,因此开展耐药检测工作十分必要。本文对耐药检测的意义、方法和应用研究最新进展加以综述,从临床和公共卫生的角度为进一步加强耐药检测工作,更有效的降低耐药的发生、传播和流行提供参考依据。

Antiviral therapy of acquired immunodeficiency syndrome（AIDS） is of great importance for virus inhibition and the survival of patients, but drug resistance of virus has been recognized as a serious threat to treatment, leading to failure of individual treatment and spreading risk of the drug resistant strains. Thus, drug resistance detection is very necessary. This paper generalizes the latest progress of significance, methods and applicative research of drug resistance to provide clinical and public health references for the further improvement of drug resistance detection and further reduction of occurrence, spreading and prevalence of drug resistance.